Senior Scientist - siRNA Design & Off-Target Analysis

AbbVie; Worcester (MA); Vor Ort; USD 120.000 - 170.000; Vollzeit

Benefits dieser Stelle

Paid time off

Medical/dental/vision insurance

401(k) plan

Short-term incentive programs

Zusammenfassung

AbbVie in Worcester, MA is seeking a Senior Scientist with deep expertise in computational biology, molecular design, and next‑generation sequencing to drive siRNA design and off-target assessment. You will establish and optimize siRNA sequences, develop off-target workflows, and integrate transcriptomic and genomic data to advance safer RNA-based therapeutics.

The role requires strong biological insight, quantitative skills, and the ability to build reproducible pipelines in Python or R,

Qualifikationen

• Advanced coursework or experience in computational biology, genomics, or RNA biology.
• Proficiency in Python and/or R with reproducible workflows.
• Experience supporting off-target analysis or risk assessment for RNA-based modalities.

Aufgaben

• Design and optimize siRNA sequences and pipelines using genomic and transcriptomic data.
• Develop machine learning models to improve sequence selection.
• Collaborate on NGS library prep for off-target analysis and integrate data for safety assessments.
• Translate transcriptomic findings into actionable biological insights.
• Develop reusable analysis tools and documentation in Python, R, or similar languages.

Kenntnisse

Python

R

Data analysis

Ausbildung

PhD in computational biology or genomics

Tools

NGS library preparation

Jobbeschreibung

AbbVie in Worcester, MA is seeking a Senior Scientist with deep expertise in computational biology, molecular design, and next‑generation sequencing to drive siRNA design and off-target assessment. You will establish and optimize siRNA sequences, develop off-target workflows, and integrate transcriptomic and genomic data to advance safer RNA-based therapeutics.

The role requires strong biological insight, quantitative skills, and the ability to build reproducible pipelines in Python or R,