Senior Scientist: siRNA Design & Off-Target Analysis

Allergan; Worcester (MA); On-site; USD 140,000 - 190,000; Full time

Job summary

AbbVie in Worcester, MA seeks a Senior Scientist to advance siRNA design and off-target assessment. You will build and optimize pipelines integrating genomic, transcriptomic, and RNA structural data, and develop machine learning models to improve sequence selection for safer RNA-based therapeutics.

The role requires strong coding in Python/R, experience with NGS analyses, and collaboration with assay scientists to translate findings into actionable insights.

Qualifications

• PhD or higher in computational biology or related field with biotech experience.
• Proficiency in Python and R with reproducible analytical workflows.
• Experience supporting off-target analysis or RNAi-related studies.

Responsibilities

• Establish, implement, and improve pipelines for siRNA sequence design using genomic and transcriptomic data.
• Build ML models based on screening data to improve siRNA selection.
• Collaborate on NGS library preparation for off-target analysis and data interpretation.
• Develop and maintain reusable analysis tools and pipelines in Python/R.
• Generate clear data analysis reports and presentations for cross-functional teams.

Skills

Python

R

NGS analysis

Education

PhD in computational biology

Tools

Git

Docker

Snakemake

Job description

AbbVie in Worcester, MA seeks a Senior Scientist to advance siRNA design and off-target assessment. You will build and optimize pipelines integrating genomic, transcriptomic, and RNA structural data, and develop machine learning models to improve sequence selection for safer RNA-based therapeutics.

The role requires strong coding in Python/R, experience with NGS analyses, and collaboration with assay scientists to translate findings into actionable insights.