Senior Scientist, siRNA Pipeline Development, Ex-hepatic

AbbVie; Cambridge (MA); Vor Ort; USD 120.000 - 160.000; Vollzeit

Zusammenfassung

AbbVie is seeking a Senior Scientist I/II to join the siRNA group in the Biotherapeutics and Genetic Medicine (BGM) department. You will design and execute innovative experimental approaches to advance oligonucleotide therapeutics and siRNA delivery for extrahepatic pipelines, driving scientific innovation and cross-functional collaboration.

The role emphasizes leading experiments, developing assays, and enabling progression across development stages while mentoring teammates and contributing to

Qualifikationen

• Experience across in vitro and in vivo siRNA delivery studies.
• Expertise in siRNA therapeutics including design and delivery systems.
• Experience with siRNA and antibody-oligo-conjugates (AOCs) is desirable.
• Strong techniques in RNA biology and biomarker quantification.

Aufgaben

• Lead cross-functional research to advance siRNA therapeutics development.
• Design and develop ex-hepatic siRNA delivery platforms for targeted delivery to tissues of interest.
• Conceive and execute proof-of-concept experiments to validate scientific hypotheses and address technical challenges with high-quality results.
• Develop in vitro, ex vivo, and in vivo assays to assess siRNA candidates and delivery technologies in support of program objectives.
• Mentor and support junior scientists within the team.

Kenntnisse

siRNA therapeutics

experimental design

cell biology

data analysis

Ausbildung

PhD in molecular biology

MS in molecular biology

BS in biology

Tools

RT-PCR

qPCR

NGS

ELISA

Western Blot

Jobbeschreibung

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Job Description

At AbbVie, we are dedicated to solving some of the world’s most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. We are looking forte… But let me include the corrected version exactly: At AbbVie, we are dedicated to solving some of the world’s most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. We are looking fortalented, passionate, and driven individuals to join our BiotherapeuticsandGenetic Medicine (BGM) team. As a Senior Scientist in our siRNA group, you will be part of an innovative team focused on advancing RNA-based therapies that have the potential to revolutionize patient care.

AbbVie is looking for a Senior Scientist I/IIto join our siRNA group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeuticsand to enable siRNA deliveryfor extrahepatic pipelinedevelopment.The successful candidate will drive scientific innovation, identify new methods and techniques, and collaborate across functions to support the development of novel RNA-based therapies.

Responsibilities

• Lead research efforts within a cross-functional team to advance siRNAtherapeuticsdevelopmentfor ex-hepaticpipelines
• Design, evaluate,and develop novelex-hepaticsiRNA delivery platformsfor targeted delivery to tissues of interest
• Conceive and execute proof-of-concept experiments to validate scientific hypotheses and address technical challenges with high-quality results.
• Developin vitro,ex vivo, andin vivoassaysto assess siRNA candidates and delivery technologies in support of program objectives.
• Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor.
• Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions.
• Acquire deep knowledge of RNA biology and siRNA therapeutics to support programs across multiple stages of development.
• Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.
• Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.
• Mentor and support junior scientists within the team.

Qualifications

• BS, MS, or PhD in molecular biology, RNA biology, cell biology, pharmaceutical sciences, biomedical engineering,or or a related scientific discipline, with typically 0-4+(PhD), 8-10+ (MS), or 10-12+ (BS) years of relevant experience.
• Hands-on experience in designing and executingin vitroandin vivostudies to evaluate siRNA deliveryplatforms,includingassessments ofcellular uptake, target knockdown, delivery efficiency and biodistribution.
• Demonstrated expertise in siRNA therapeutics, includingthedesign, development, characterization and optimizationofsiRNAsequences anddelivery systems.

• Proven experiencewithsiRNAand antibody-oligo-conjugates (AOCs) is highly desirable.

• Extensive hands-onexperience and techniques formolecular andRNA biology, including cell culture, RNA extraction, RNA quantification (RT-PCR, qPCR,ddPCR),next-generation sequencing (NGS),protein quantification (ELISA, Western Blot, JESS), flowcytometryandother biomarker quantification.

• Proven ability todevelop,troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.

• Highly self-motivatedand capable ofthrivingin a fast-paced, collaborative team environment.

• Strong written and verbal communication skills,withexperience contributing to technical reports, publications, or regulatory documentation.

Why AbbVie?

AbbVie is a global biopharmaceutical company committed to bringing innovative medicines to patients in need. We offer a collaborative work environment, opportunities for professional growth, and the ability to make an impact on the future of healthcare. Join us and be part of a team that is transforming the landscape of genetic medicine.

Additional Information

• The compensation range described below is the range