Senior Scientist, Single-Cell Assay Development (10x)

10x Genomics Inc; San Francisco (CA); On-site; USD 140,000 - 189,000; Full time

Job summary

10x Genomics Inc in San Francisco is seeking an experienced scientist to lead the development and optimization of single cell assays within the Single Cell Biology group. This full-time role involves hands-on molecular biology, NGS library preparation, and troubleshooting to advance internal workflows and support customers.

You will collaborate across Molecular/Cell Biology, Chemistry, Fluidics, and Computational Biology, mentoring junior staff and influencing design decisions for new assay

Qualifications

• Ph.D. or Master’s/BS in chemistry, molecular biology, biochemistry, cell biology, or related field.
• 7+ years (BS/MS) or 3+ years (PhD) of biotech/pharma industry experience.
• Proficiency in nucleic acid extraction, PCR/qPCR, and NGS library prep.
• Hands-on experience with advanced molecular technologies and NGS workflows.
• Experience with experimental design and statistical data analysis.
• Ability to plan multi-step experiments with meticulous record-keeping.
• Experience with challenging clinical samples (e.g., FFPE, primary tumor cells, low-input).
• Strong collaboration and mentoring skills; able to thrive in a fast-paced startup.

Responsibilities

• Lead testing and troubleshooting of new assay sub-systems and existing single cell workflows, including sample processing, library preparation, sequencing, and data analysis
• Prepare high-quality NGS libraries and independently optimize established molecular biology protocols
• Contribute to conception and implementation of solutions to complex technical challenges, and contribute to design decisions for new assay systems
• Master the use of existing tools and defined methods, and lead their improvement
• Conceive of and develop new tools and methods to advance assay development capabilities
• Analyze and interpret experimental data to draw conclusions and determine next steps
• Generate intra-functional and cross-functional project sub-task plans, and contribute to broader project plans
• Begin to provide technical guidance to junior functional team members
• Partner with R&D, Support, and Marketing to drive assay development priorities and customer-facing troubleshooting

Skills

PCR/qPCR

NGS library prep

Nucleic acid extraction

Molecular biology techniques

Experimental design

Statistical data analysis

Education

BS/MS/PhD in Chemistry or Molecular Biology or related

Tools

NGS workflows

Job description

10x Genomics Inc in San Francisco is seeking an experienced scientist to lead the development and optimization of single cell assays within the Single Cell Biology group. This full-time role involves hands-on molecular biology, NGS library preparation, and troubleshooting to advance internal workflows and support customers.

You will collaborate across Molecular/Cell Biology, Chemistry, Fluidics, and Computational Biology, mentoring junior staff and influencing design decisions for new assay