Senior Scientist, Protein Purification & Enzymology

1000 Pacific Biosciences of California, Inc.; Menlo Park (CA); On-site; USD 129,000 - 193,000; Full time

Job summary

Pacific Biosciences of California, Inc. is seeking a Senior Scientist in Biochemistry R&D to lead protein expression, purification, and characterization of nucleic acid–modifying enzymes.

The role requires deep purification expertise, enzymology know‑how, and the ability to design high‑throughput pipelines at research scale. You will collaborate with cross‑functional teams, design quantitative assays, and ensure QC of purified enzymes for library preparation and sequencing workflows.

Qualifications

• PhD with 2–5 years post-PhD industry experience preferred.
• Hands-on protein expression and purification of recombinant proteins and complexes.
• Experience with FPLC and chromatography method development.

Responsibilities

• Build and optimize purification pipelines for nucleic acid–modifying enzymes at multiple scales.
• Serve as purification SME and advise on construct design and purification strategies.
• Develop expression/purification strategies for challenging targets; maximize yield and purity.

Skills

Protein purification

Enzymology

FPLC

High-throughput screening

Protein expression

Analytical techniques

Team collaboration

Communication skills

Education

PhD in Biochemistry, Molecular Biology, Biophysics, Chemistry, Bioengineering

Tools

ÄKTA FPLC

KingFisher

Tecan

Opentrons

Hamilton

Job description

Pacific Biosciences of California, Inc. is seeking a Senior Scientist in Biochemistry R&D to lead protein expression, purification, and characterization of nucleic acid–modifying enzymes.

The role requires deep purification expertise, enzymology know‑how, and the ability to design high‑throughput pipelines at research scale. You will collaborate with cross‑functional teams, design quantitative assays, and ensure QC of purified enzymes for library preparation and sequencing workflows.