Senior Scientist, Microglia Therapeutics for Alzheimer's

Retro Biosciences; Redwood City (CA); In loco; USD 150.000 - 190.000; Tempo pieno

Vantaggi offerti da questo lavoro

Medical, dental, and vision insurance

401(k) plan with 4% matching

Flexible time off and 10 company days

Paid parental leave

Annual learning & development stipend

Longevity stipend

Lunch and snacks provided

Descrizione del lavoro

Retro is seeking an experienced, hands-on scientist to join its Microglia Therapeutics team and drive discovery research in Alzheimer’s disease. You will develop in vitro and in vivo disease models, establish assays, and interpret experiments to investigate the therapeutic potential of our microglial cell therapy.

You have a Ph.D. in Neuroscience or related field with 3+ years of post‑degree experience, strong mammalian cell culture and imaging skills, and a track record of designing robust

Competenze

• Ph.D. in Neuroscience, Biology, or related field and at least 3 years of post‑degree experience.
• At least 3 years hands-on Alzheimer’s disease research with in vitro/in vivo models.
• Strong mammalian cell culture skills and iPSC‑derived neural cell types experience.
• Developed and optimized cell‑based and molecular assays for function or disease phenotypes.
• Experience with brain tissue immunostaining, fluorescence/confocal microscopy, and quantitative image analysis.

Mansioni

• Design and execute discovery experiments to evaluate microglial cell therapy in Alzheimer's disease.
• Culture and differentiate iPSCs into CNS cell types and optimize 2D/3D protocols.
• Develop 2D/3D disease models to study responses to Alzheimer's challenges.
• Design and optimize in vivo modeling approaches, including readouts for engraftment and pathology.
• Develop cellular and molecular assays to evaluate microglial function and phenotypes.
• Perform staining and imaging of cells, organoids, and brain tissue; interpret results.
• Collaborate with histology/imaging colleagues and integrate findings across studies.
• Present results to internal teams and collaborators; maintain organized ELN entries.

Conoscenze

Cell culture

Immunostaining

Fluorescence microscopy

Image analysis

Experimental design

Formazione

Ph.D. in Neuroscience or related field

Strumenti

iPSC culture

Confocal microscopy

Descrizione del lavoro

Retro is seeking an experienced, hands-on scientist to join its Microglia Therapeutics team and drive discovery research in Alzheimer’s disease. You will develop in vitro and in vivo disease models, establish assays, and interpret experiments to investigate the therapeutic potential of our microglial cell therapy.

You have a Ph.D. in Neuroscience or related field with 3+ years of post‑degree experience, strong mammalian cell culture and imaging skills, and a track record of designing robust