Scientist II - LNP Formulation

TALENT Software Services; San Diego (CA); On-site; USD 85,000 - 120,000; Full time

Job summary

TALENT Software Services seeks a motivated Scientist 1 to join our Formulation team in San Diego. You will help synthesize and optimize lipid nanoparticles for nucleic acid delivery, working closely with senior scientists in a hands-on lab environment.

The role emphasizes LNP encapsulation, DoE-driven optimization, thorough data analysis, and cross-functional support for early-stage development. Strong detail orientation and collaboration are essential.

Qualifications

• Bachelor’s degree in Chemistry, Biochemistry, Chemical Engineering, or related discipline with 5+ years biopharma experience, OR Master’s with 2+ years.
• Proficiency in LNP formulation and nucleic acid encapsulation (mRNA, siRNA, or DNA).
• Experience with standard LNP characterization methods and data analysis.

Responsibilities

• Execute and optimize formulation and characterization of lipid nanoparticles for in vitro and in vivo studies.
• Implement DoE based screening campaigns to optimize LNP compositions and processing parameters.
• Collaborate cross-functionally to support formulation requests.
• Support early-stage formulation development and downstream processing activities.
• Maintain detailed records of formulation activities and results.
• Analyze, interpret, and present experimental data to the team.
• Contribute to routine lab management such as inventory tracking and buffer preparation.

Skills

LNP formulation

DoE screening

Data analysis

DLS characterization

Zeta potential

Ribogreen assays

MS Excel

JMP

Prism

Education

Bachelor’s degree in Chemistry/Biochemistry/Chemical Engineering

Master’s degree in related field (biopharma)

Tools

Dynamic Light Scattering (DLS)

Zeta potential

Ribogreen assay

Job description

Onsite: San Diego, CA. No relocations.

Max Client Bill Rate: ***

Position Summary

We are seeking a motivated and detail-oriented Scientist 1 to join our Formulation team. In this hands-on laboratory role, you will work closely with senior scientists to execute and optimize the synthesis of targeted and non-targeted lipid nanoparticles (LNPs) for nucleic acid delivery. The successful candidate will be a collaborative team player with strong technical and data analysis skills who is ready to contribute to our non-viral delivery platform.

Responsibilities

• Execute and optimize the formulation and characterization of lipid nanoparticles (LNPs) or targeted lipid nanoparticle (tLNPs) encapsulating nucleic acids for in vitro and in vivo studies under the minor guidance of senior formulation scientists.
• Implement Design of Experiment (DoE) based screening campaigns to evaluate and establish optimal LNP compositions and processing parameters.
• Collaborate cross-functionally with internal teams to support and fulfill formulation requests.
• Support early-stage formulation development and downstream processing activities when needed, including cryoprotection, scale-up, and stability studies.
• Maintain detailed records documenting formulation activities and results.
• Analyze, interpret, and present experimental data to the formulation team.
• Contribute to routine lab management activities, including inventory tracking, supply ordering, buffer preparation, and autoclaving.

Requirements, Knowledge, Skills, and Abilities

• Bachelor’s degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 5+ years of biopharma industry experience, OR a Master’s degree with 2+ years of industry experience.
• LNP Expertise: Minimum of 2 years of hands‑on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA).
• Analytical Skills: Proficiency with standard LNP characterization methods, including Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays.
• Software & Data: High proficiency in MS Excel is required; hands‑on experience with statistical and data analysis software (e.g., JMP, Prism) is preferred.
• Core Competencies: Strong attention to detail, a track record of producing reproducible data, excellent organizational skills, and the ability to communicate effectively within a fast-paced team environment.
• Preferred Skills: Prior experience with targeted LNP preparation (mAb, Fab, ScFv, VHH coated LNP) and immune cell delivery is highly desirable.