Senior Scientist, In Vivo CAR-T Vector Delivery

Synectics Inc.; Gaithersburg (MD); Sur place; USD 120 000 - 180 000; Plein temps

Avantages offerts par ce poste

Healthcare Insurance

Dental Insurance

Vision Insurance

401(k) Plan

Résumé du poste

Synectics Inc. is seeking a Senior Scientist to advance in vivo CAR‑T delivery using lentiviral vectors. The role emphasizes vector engineering, transduction analysis, and close collaboration with cross-functional teams to drive innovative in vivo strategies for CAR‑T therapies.

You will own experimental strategy, generate producer cell lines, and develop assays to quantify vector potency and target cell specificity, contributing to GMP-like documentation and readiness for audits.

Qualifications

• PhD or MS with industry experience in Cell Therapy, Virology, Immunology, or related field.
• Extensive hands-on CAR-T cell therapy development experience, in ex vivo or in vivo settings.
• Deep expertise in lentiviral vector engineering, production, and QC.
• Advanced knowledge of primary T cell biology and functional assay development.
• Hands-on mammalian cell culture, including cancer cell lines and primary T cells.
• Advanced multicolor flow cytometry, including panel design and analysis.
• Strong documentation and scientific communication skills.
• Recent PhD graduates considered with strong lab/research experience; industry experience preferred.

Responsabilités

• Own experimental strategy and drive vector engineering and in vivo delivery platform development.
• Generate and characterize stable producer cell lines and perform clone screening.
• Design and execute complex vector engineering and validation strategies for in vivo CAR delivery.
• Develop flow cytometry-based assays to quantify transduction and CAR‑T phenotype.
• Maintain GMP-like documentation and data traceability for audits.
• Identify knowledge gaps and propose new approaches or improvements.
• Communicate findings clearly to cross-functional stakeholders.
• Support CAR‑T therapy research focusing on in vivo LVV platform.

Connaissances

CAR‑T cell therapy

Lentiviral vector engineering

Flow cytometry

Primary T cell culture

In vivo delivery

Data interpretation

Formation

PhD or MS with industry experience in Cell Therapy/Virology/Immunology

Outils

Mammalian cell culture

Stable producer cell lines

Lentivirus production

Multicolor flow cytometry

Description du poste

Synectics Inc. is seeking a Senior Scientist to advance in vivo CAR‑T delivery using lentiviral vectors. The role emphasizes vector engineering, transduction analysis, and close collaboration with cross-functional teams to drive innovative in vivo strategies for CAR‑T therapies.

You will own experimental strategy, generate producer cell lines, and develop assays to quantify vector potency and target cell specificity, contributing to GMP-like documentation and readiness for audits.