Lentiviral CAR-T Scientist for In Vitro Assay Development

AbbVie; South San Francisco (CA); Presencial; USD 150.000 - 210.000; Jornada completa

Descripción de la vacante

AbbVie seeks a Senior Scientist to join Genetic Medicine in vivo CAR-T. You will design and execute experiments to advance lentiviral-based delivery platforms, engineer vectors, and collaborate across teams to push the CAR-T program from discovery through translational development.

You will mentor junior scientists, author publications and assist in patent work, while maintaining rigorous ELN records and ensuring safety in a BSL-2 environment.

Formación

• Expertise in mammalian primary cell and cell line culture, including T cells and PBMCs.
• Experience with multi-color flow cytometry and immunoassays such as ELISA or Luminex.
• Proven ability to develop and troubleshoot high-throughput assays.
• Experience with lentiviral vector design, production, and analysis is highly preferred.
• Strong communication, collaboration, and scientific documentation skills.

Responsabilidades

• Lead research efforts and design in vitro studies to advance lentiviral delivery platforms.
• Engineer lentiviral vectors and fusion receptors; oversee production via internal/external partners.
• Collaborate with cross-functional teams to advance CAR-T pipeline from discovery to translational development.
• Maintain thorough ELN records and interpret multidisciplinary data to guide experiments.
• Contribute as a primary author to publications and patent applications; mentor junior scientists.

Conocimientos

Flow cytometry

ELISA

ddPCR

Lentiviral vectors

CAR-T therapy

Mammalian cell culture

Immunology

Data analysis

Publications

Regulatory documentation

Educación

PhD in immunology (or related)

MS in biology or related field

BS in biology or related field

Herramientas

Luminex

qPCR

Transduction efficiency analysis

Titering

CRISPR editing (optional)

Descripción del empleo

AbbVie seeks a Senior Scientist to join Genetic Medicine in vivo CAR-T. You will design and execute experiments to advance lentiviral-based delivery platforms, engineer vectors, and collaborate across teams to push the CAR-T program from discovery through translational development.

You will mentor junior scientists, author publications and assist in patent work, while maintaining rigorous ELN records and ensuring safety in a BSL-2 environment.