Senior Scientist — In Vivo CAR-T Vector Engineering

KellyOCG; Gaithersburg (MD); On-site; USD 69,000 - 99,000; Full time

Job summary

AstraZeneca in Gaithersburg, MD is seeking a Senior Scientist to lead in vivo CAR vector engineering for delivery platforms and T cell targeting. You will own experimental strategy, drive innovation, and work with cross-functional teams to meet therapeutic objectives.

PH/MS with biotech experience and strong expertise in CAR‑T development, lentiviral vectors, and flow cytometry are required. GMP‑like documentation and clear scientific communication are essential for success.

Qualifications

• PhD or MS with industry experience in Cell Therapy, Virology, Immunology, Bioengineering, or related discipline
• Extensive hands-on CAR‑T therapy development experience (ex vivo or in vivo)
• Multicolor flow cytometry experience
• Expertise in lentiviral vector engineering, production and QC
• Advanced knowledge of primary T cell biology and functional assays
• Hands-on mammalian cell culture, including cancer lines and primary T cells
• Advanced multicolor flow cytometry design, acquisition, analysis, interpretation
• Strong documentation and scientific communication skills

Responsibilities

• Generate and characterize stable producer cell lines, including clone screening, selection, and banking
• Design, prioritize, and execute complex vector engineering and validation strategies for in vivo CAR delivery
• Own functional assessment strategy for vector potency and transduction, selecting appropriate assays and defining success criteria
• Develop and execute flow cytometry–based assays to quantify transduction, target‑cell specificity, and CAR‑T phenotype and function
• Ensure GMP grade like documentation standards, data traceability, and readiness for internal review or audit
• Make independent technical decisions that impact project direction and experimental prioritization
• Identify knowledge gaps and proactively propose new approaches or technology improvements
• Communicate complex findings clearly and persuasively to cross‑functional stakeholders

Skills

CAR‑T technology

Flow cytometry

T cell biology

Vector engineering

In vivo delivery

Scientific independence

Data interpretation

Education

PhD or MS in Cell Therapy, Virology, Immunology, Bioengineering or related discipline

Tools

Lentiviral vector production

Flow cytometry instruments

Mammalian cell culture

Job description

AstraZeneca in Gaithersburg, MD is seeking a Senior Scientist to lead in vivo CAR vector engineering for delivery platforms and T cell targeting. You will own experimental strategy, drive innovation, and work with cross-functional teams to meet therapeutic objectives.

PH/MS with biotech experience and strong expertise in CAR‑T development, lentiviral vectors, and flow cytometry are required. GMP‑like documentation and clear scientific communication are essential for success.