Scientist II

Talent Software Services, Inc.; South San Francisco (CA); In loco; USD 90.000 - 120.000; Tempo pieno

Descrizione del lavoro

The gRED Cell Therapy Department at Talent Software Services, Inc. is seeking a Scientist for a contingent position to support in vivo cell therapy research. This hands-on role focuses on research-scale lentiviral vector production, vector characterization, and analytical assay development.

The Scientist may also prepare materials for preclinical in vivo studies while not conducting animal work. Successful candidates will have strong experimental judgment, expertise in vector production and

Competenze

• The candidate holds BS/MS with 5+ years in industry or a PhD in a relevant field.
• Hands-on lentiviral vector production and characterization experience.
• Proficiency in aseptic mammalian cell culture and primary human immune cells.
• Experience in developing and troubleshooting molecular or cell-based assays.
• Technical skill in flow cytometry and at least one quantitative assay platform.
• Ability to independently design experiments and interpret data.

Mansioni

• Execute and optimize research-scale lentiviral vector production workflows.
• Produce and characterize vectors for in vitro evaluation and preclinical studies.
• Develop molecular and cell-based assays to assess quality and activity.
• Perform primary human cell culture and engineering studies for delivery platforms.
• Apply flow cytometry to assess transduction, CAR expression, and phenotype.
• Collaborate with teams to define material needs and timelines.
• Plan experiments, troubleshoot, and interpret results with the team.
• Communicate findings through summaries and internal talks.
• Maintain accurate electronic lab records and reproducible workflows.
• Support laboratory operations and biosafety/training requirements.

Conoscenze

Lentiviral vector production

Mammalian cell culture

Flow cytometry

Experimental design

Formazione

BS/MS or PhD in a related field

Strumenti

qPCR

ddPCR

Descrizione del lavoro

Schedule: M-F 9am-5pm 1 year contract w/ a possible extension Interviews: 1. phone screen 2. in person panel

Position Overview

The gRED Cell Therapy Department at *** is seeking a motivated and scientifically curious Scientist for a contingent position supporting in vivo cell therapy research. This hands-on, laboratory-based role will focus on research-scale lentiviral vector production, vector characterization, and analytical assay development. The Scientist may also generate and characterize materials for use in preclinical in vivo studies conducted by collaborating teams. This position does not involve conducting animal studies.

The successful candidate will bring strong experimental judgment, technical expertise in vector production and cell-based analytics, and a collaborative approach to advancing research programs.

Key Responsibilities

• Execute and optimize research-scale lentiviral vector production workflows, including approaches that support increased production capacity and transition to suspension culture.
• Produce and characterize research-grade lentiviral vectors for in vitro evaluation and, as needed, to support preclinical in vivo studies.
• Develop, optimize, and execute molecular and cell-based assays to assess vector quality, titer, gene delivery, CAR expression, and functional activity.
• Perform primary human cell culture and engineering studies to support evaluation of delivery platforms for in vivo cell therapy applications.
• Apply flow cytometry to assess transduction efficiency, CAR expression, and cell phenotype.
• Collaborate with project teams to define material requirements, coordinate production timelines, and provide supporting analytical data.
• Independently plan experiments, troubleshoot technical challenges, and interpret results in collaboration with project team members.
• Analyze and communicate findings through clear experimental summaries and presentations at internal scientific meetings.
• Maintain accurate and timely electronic laboratory records, document methods, and contribute to reproducible workflows.
• Support laboratory operations, including equipment onboarding and maintenance, and adhere to applicable biosafety, laboratory safety, and training requirements.

Required Qualifications

• A self-motivated candidate with a (BS/ MS) + 5 years industry experience, or PhD in Immunology, Virology, Molecular Biology, Bioengineering, Cell Biology, or a related discipline.
• Hands-on experience with lentiviral vector production and characterization.
• Strong proficiency in aseptic mammalian cell culture and experience working with primary human immune cells, preferably T cells.
• Experience developing, optimizing, and troubleshooting molecular or cell-based analytical assays.
• Technical proficiency in flow cytometry and at least one quantitative molecular assay platform, such as qPCR or ddPCR.
• Demonstrated ability to independently design experiments, critically interpret data, and resolve technical challenges.
• Strong organizational, documentation, and communication skills, with the ability to manage concurrent experiments and collaborate effectively.

Preferred Qualifications

• Three or more years of relevant post-graduate research experience in biotechnology, pharmaceutical research, or an academic setting.
• Experience producing or characterizing gene delivery vectors for in vivo CAR T or related preclinical research programs.
• Experience with suspension-based lentiviral vector production, scale-up, or process development.
• Experience with CAR T-cell functional assays and multiparameter flow cytometry.
• Experience with nonviral delivery platforms, genome engineering, or next-generation sequencing.
• Familiarity with automation, liquid handling, and high-throughput analytical workflows.
• Proficiency with relevant analysis and documentation tools, such as FlowJo, GraphPad Prism, and Benchling.