Senior Scientist II: Engineered Liver Tissue & Hepatocytes

Harvard University; Boston (MA); On-site; USD 150,000 - 210,000; Full time

Benefits offered by this job

Medical, dental and vision insurance

Job summary

Wyss Institute at Harvard University is seeking a Senior Scientist II to provide scientific and technical leadership for hepatocyte engineering within a federally funded program focused on engineered liver tissue for liver failure treatment.

You will expand, engineer, and characterize hepatocytes, integrate them into tissue constructs, and work with teams across Harvard and partner institutions to advance translational goals.

Qualifications

• Master’s degree in Cell Biology, Molecular Biology, Bioengineering, Biomedical Engineering, Biomedical Science, or related field.
• Minimum of 9 years of relevant research experience in an academic, research institute or industry setting.

Responsibilities

• Lead hepatocyte-focused experiments and analyses for the program’s workstream.
• Expand, mature and maintain functional human hepatocytes; develop genetic engineering strategies to modulate immunogenicity.
• Collaborate across tissue engineering, vascularization, and in vivo teams to integrate hepatocytes into tissue constructs and animal models.
• Lead milestone planning, sponsor reporting, and program reviews; contribute to publications and IP strategy.
• Ensure rigorous documentation, quality control, and safe lab operations.

Skills

Hepatocyte expansion

Genetic engineering

CRISPR/Cas9

Cell culture

In vivo models

Assay development

Data analysis

Team leadership

Education

Master’s degree in Cell Biology/Biomedical Engineering or related field

Tools

CRISPR/Cas9 editing

Viral/non-viral gene delivery

Bioreactor systems

Job description

Wyss Institute at Harvard University is seeking a Senior Scientist II to provide scientific and technical leadership for hepatocyte engineering within a federally funded program focused on engineered liver tissue for liver failure treatment.

You will expand, engineer, and characterize hepatocytes, integrate them into tissue constructs, and work with teams across Harvard and partner institutions to advance translational goals.