Senior Scientist II - Hepatocyte & Liver Tissue Engineering

Wyss Institute at Harvard University; Boston (MA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Generous paid time off

Medical, dental, and vision insurance

Retirement plan

Tuition assistance

Job summary

The Wyss Institute at Harvard University in Boston is seeking a Senior Scientist II to lead hepatocyte engineering within a multi-institution program. You will design and conduct core experiments, advance hepatocyte expansion, and develop immune-modulating strategies to support engineered liver tissue.

Reporting to the Senior Director of Translational R&D and collaborating with cross-functional teams across Wyss, Boston University, and partner institutions, you will mentor staff, contribute to

Qualifications

• Master’s degree in Cell Biology, Molecular Biology, Bioengineering or related field and 9+ years of relevant research experience.
• PhD strongly preferred in related fields.
• Extensive hands-on experience in human cell culture and hepatocyte engineering.
• Experience with genome engineering and immune-phenotype assays.
• Ability to work independently and in cross-functional teams.

Responsibilities

• Lead hepatocyte workstream experiments, planning and analysis.
• Expand, mature and maintain functional human hepatocytes.
• Develop CRISPR/Cas9 and other gene-editing approaches to modulate immunogenicity.
• Characterize hepatocyte identity, function and immune phenotype.
• Collaborate with tissue integration and in vivo teams to evaluate engraftment.

Skills

Hepatocyte culture

CRISPR/Cas9

Molecular biology

Data analysis

Education

Master’s degree in Cell Biology

PhD preferred

Tools

Bioreactor systems

cGMP manufacturing

Job description

The Wyss Institute at Harvard University in Boston is seeking a Senior Scientist II to lead hepatocyte engineering within a multi-institution program. You will design and conduct core experiments, advance hepatocyte expansion, and develop immune-modulating strategies to support engineered liver tissue.

Reporting to the Senior Director of Translational R&D and collaborating with cross-functional teams across Wyss, Boston University, and partner institutions, you will mentor staff, contribute to