Scientist, Epigenetic Liver Reprogramming

Pharmadog; South San Francisco (CA); On-site; USD 130,000 - 165,000; Full time

Benefits offered by this job

Health insurance

Dental insurance

Vision insurance

401(k) match

Paid parental leave

PTO 20 days

Meals on-site

Job summary

NewLimit seeks a Scientist on the Metabolism team to advance liver biology research and develop assays for hepatocyte function. You will collaborate with the Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design epigenetic reprogramming interventions for aged hepatocytes in metabolic disease.

This role involves delivering perturbations in vivo using viral vectors or lipid nanoparticles, analyzing data to guide preclinical decisions, and contributing to strategy for

Qualifications

• Ph.D. in cell biology, molecular biology, biochemistry or related field with 5+ years industry experience.
• Experience with primary liver cell isolation and functional characterization.
• Experience with mouse models of liver dysfunction.
• Experience with transgenic manipulation of liver cells ex vivo or in vivo.
• Strong organizational skills and ability to manage multiple projects.

Responsibilities

• Collaborate with Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes.
• Develop assays to preclinical models of liver disease to measure hepatocyte function.
• Evaluate epigenetic reprogramming payloads using in vivo functional assays to select therapeutic candidates.
• Deliver epigenetic perturbations to hepatocytes in vivo using viral vectors or lipid nanoparticles.
• Analyze and interpret experimental data to drive pre-clinical decision making.

Skills

Liver biology

Mouse models

Transgenic delivery

Organizational skills

Education

Ph.D. in cell biology

Tools

Viral vectors

Nucleic acid delivery

Job description

NewLimit seeks a Scientist on the Metabolism team to advance liver biology research and develop assays for hepatocyte function. You will collaborate with the Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design epigenetic reprogramming interventions for aged hepatocytes in metabolic disease.

This role involves delivering perturbations in vivo using viral vectors or lipid nanoparticles, analyzing data to guide preclinical decisions, and contributing to strategy for