Senior Scientist, Functional Genomics & HTS - Flexible Work

Amgen SA; Thousand Oaks (CA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Total Rewards Plan

Competitive benefits

Flexible work models

Job summary

Amgen seeks a Senior Scientist in Functional Genomics and High-Throughput Screening to translate data into discovery, building advanced in vitro models and scalable screening platforms across Amgen’s therapeutic areas.

You will work in a dynamic, cross-functional team, collaborating with automation and TD&B colleagues to accelerate model deployment, optimize protocols, and deliver robust biological insights for target discovery.

Qualifications

• PhD, PharmD, MD, or equivalent in a life sciences field as listed in the basic qualifications.
• Strong background in functional genomic screening and in vitro model systems.
• Experience with genome engineering approaches and data-driven discovery is preferred.

Responsibilities

• Collaborate with therapeutic area scientists to leverage cellular models and gene delivery methods to capture disease-relevant biology.
• Design, optimize, and execute functional arrayed genomic screens in advanced in vitro models (e.g., iPSC-derived cells, organoids).
• Partner with TD&B and automation colleagues to accelerate model deployment and reproducibility.
• Identify and implement emerging technologies in high-content imaging and complex model systems to enhance discovery throughput.
• Foster a collaborative, scientifically rigorous team culture delivering impact across Amgen’s pipeline.

Skills

CRISPR screening (arrayed)

high-content imaging

cell engineering

in vitro models

viral vector systems

iPSC-derived models

data analysis

automation

team collaboration

Education

PhD

PharmD

MD

Master’s degree with 3 years functional genomic screening experience

Bachelor’s degree with 5 years functional genomic screening experience

Tools

AAV vectors

Lentivirus vectors

Automation platforms

Job description

Amgen seeks a Senior Scientist in Functional Genomics and High-Throughput Screening to translate data into discovery, building advanced in vitro models and scalable screening platforms across Amgen’s therapeutic areas.

You will work in a dynamic, cross-functional team, collaborating with automation and TD&B colleagues to accelerate model deployment, optimize protocols, and deliver robust biological insights for target discovery.