Senior/Principal Scientist — Functional Assay Development

Prellis Biologics; Berkeley (CA); On-site; USD 150,000 - 210,000; Full time

Benefits offered by this job

Health insurance

Dental insurance

Vision insurance

Life insurance

Disability insurance

401(k) plan

Stock-based long-term incentives

Holiday package

Flexible work models

Job summary

Prellis Biologics is seeking a Senior / Principal Scientist to lead functional assay development for antibody discovery. This bench-focused role emphasizes cardiometabolic biology and collaboration across Discovery, Protein Sciences, Cell Line Development, and Data Science to scale assays from concept to routine use.

On-site lab work is required as the team expands its rapidly growing pipeline. You will design, optimize, and validate functional cell-based assays, drive go/no-go decision-making,

Qualifications

• Hands-on experience developing cell-based functional assays from scratch.
• Strong hands-on experience with mammalian cell lines, including stable cell line generation.
• Familiarity with high-content imaging platforms is a plus.

Responsibilities

• Design, optimize, and validate cell-based functional assays from concept to routine screening.
• Translate target biology into assay designs for go/no-go decisions across discovery programs.
• Run functional assays against screening queue with high data quality and throughput.
• Coordinate with Cross-functional teams to align functional assay requirements with program priorities.
• Evaluate and implement assay miniaturization and automation to scale capacity.
• Prepare clear reports summarizing results and assay strategy recommendations.

Skills

Cell-based assays

Mammalian cell culture

High-content imaging

Independent researcher

Cross-functional collaboration

Problem solving

Education

Ph.D. in Cell Biology or related field

Job description

Prellis Biologics is seeking a Senior / Principal Scientist to lead functional assay development for antibody discovery. This bench-focused role emphasizes cardiometabolic biology and collaboration across Discovery, Protein Sciences, Cell Line Development, and Data Science to scale assays from concept to routine use.

On-site lab work is required as the team expands its rapidly growing pipeline. You will design, optimize, and validate functional cell-based assays, drive go/no-go decision-making,