Senior Scientist, Analytical Development (Large Molecule)

Scorpion Therapeutics; San Diego (CA); On-site; USD 150,000 - 230,000; Full time

Job summary

Scorpion Therapeutics is recruiting a Lead Analytical Development Scientist to shape analytical strategies for peptides, bioconjugates and biologics from preclinical through commercialization. You will lead method development, validation and transfer while driving CMC and regulatory readiness.

The role requires hands-on expertise in LC, iCIEF, CE and MS, with a track record across drug substance and drug product development.

Qualifications

• Hands-on experience in analytical method development, validation, and transfer.
• Experience supporting drug substance and drug product development.
• Knowledge of cGMP and regulatory guidelines (FDA, EMA, ICH).
• Strong communication and problem-solving skills.

Responsibilities

• Develop and optimize analytical techniques (e.g., LC, mass spectrometry, capillary electrophoresis).
• Support formulation and process development.
• Contribute to CMC and regulatory activities.
• Serve as analytical lead on cross-functional teams.
• Manage external testing and collaborations.
• Address complex characterization challenges through innovative approaches.

Skills

Strong communication

Problem solving

Cross-functional collaboration

Education

BS/BA in Analytical Chemistry or related field

MS in Analytical Chemistry

PhD in Analytical Chemistry

Tools

LC

iCIEF

CE

Mass spectrometry

Job description

Role

Lead analytical development for peptides, bioconjugates, and biologics from preclinical to commercialization, focusing on characterization, method validation, and transfer.

Responsibilities

develop and optimize analytical techniques (e.g., LC, mass spectrometry, capillary electrophoresis), support formulation and process development, contribute to CMC and regulatory activities, and ensure compliance with cGMP. Serve as an analytical lead on cross-functional teams, manage external testing and collaborations, and address complex characterization challenges through innovative approaches.

Requirements

BS/BA with 12+ years, MS with 10+ years, or PhD with 4+ years in Analytical Chemistry or related field; extensive hands-on experience in analytical method development, validation, and transfer; proficiency with LC, iCIEF, CE, MS, and additional characterization techniques; experience supporting drug substance and drug product development; strong communication and problem-solving skills; knowledge of cGMP, regulatory guidelines (FDA, EMA, ICH).

High-Value

biologics, peptides, bioconjugates, complex modalities, drug substance and drug product phases, CMC, regulatory compliance.

Collaboration

cross-functional teams, external labs, and partners.

WorkSetup

not specified.