Sr. Scientist

Scorpion Therapeutics; Missouri; On-site; USD 120,000 - 160,000; Full time

Job summary

Scorpion Therapeutics in Missouri seeks a Senior Scientist specializing in bioanalytical method development using LC-MS/MS and HRMS for large and small molecules, supporting drug discovery and development programs.

You will develop sensitive methods for proteins, antibodies, ADCs, and oligonucleotides, troubleshoot assays, oversee transfer, mentor junior staff, and ensure compliance with GxP and safety standards in a lab environment.

Qualifications

• PhD in Organic Chemistry, Biochemistry, or Analytical Chemistry with 2+ years of industrial bioanalytical experience.
• Strong expertise in LC-MS/MS, HRMS, and method development.
• Knowledge of GxP, SOPs, and laboratory safety.

Responsibilities

• Develop sensitive and robust bioanalytical methods for diverse molecules (proteins, antibodies, ADCs, oligonucleotides).
• Troubleshoot complex assays.
• Oversee method transfer and implementation.
• Communicate project progress.
• Mentor junior staff.

Skills

LC-MS/MS

HRMS

Bioanalytical Method Development

GxP Compliance

Troubleshooting

Mentoring

Project Communication

Cross-functional Collaboration

LC-MS/MS Instrumentation

HRMS Instrumentation

Education

PhD in Organic Chemistry

MSc in Analytical Chemistry

Tools

SOPs

Analytical Instrumentation

Job description

Senior Scientist specializing in bioanalytical method development using LC-MS/MS and HRMS for large and small molecules, supporting drug discovery and development programs.

Responsibilities

• develop sensitive and robust bioanalytical methods for diverse molecules (proteins, antibodies, ADCs, oligonucleotides)
• troubleshoot complex assays
• oversee method transfer and implementation
• communicate project progress
• mentor junior staff

Requirements

• PhD in Organic Chemistry, Biochemistry, or Analytical Chemistry with 2+ years or MSc with 5+ years of industrial bioanalytical experience
• strong expertise in LC-MS/MS, HRMS, and method development
• knowledge of GxP, SOPs, and laboratory safety

Preferred

• experience with biotherapeutics, bioconjugates, or biopharmaceutical modalities
• familiarity with in vitro metabolism and PK modeling

HighValue

biologics, ADCs, oligonucleotides, bioanalytical method development, regulatory compliance, GxP environment, and cross-functional collaboration with research and development teams.

WorkSetup

typically laboratory environment, with potential safety hazards due to hazardous materials; physical work may involve exposure to biohazards.