Principal Scientist, Analytical Development, Oligonucleotide & Small Molecule CMC

Scorpion Therapeutics; South San Francisco (CA); On-site; USD 180,000 - 240,000; Full time

Job summary

Scorpion Therapeutics seeks a senior scientist to lead and mentor the CMC Analytical Development team, overseeing method development, testing, and characterization for biotherapeutics crossing the blood-brain barrier.

You will drive analytical strategy across oligonucleotide and small-molecule programs, validate methods, and coordinate CROs/CDMOs and regulatory submissions, ensuring rigorous GxP compliance and robust data packages.

Qualifications

• Ph.D. in Chemistry, Pharmaceutical Sciences, or related discipline with 7+ years (Ph.D.) or 10+ years (M.S.) or 12+ years (B.S.) of industry experience.
• 5+ years hands-on analytical development supporting oligonucleotide and/or small-molecule drug substances/products.
• Expertise in chromatographic techniques and mass spectrometry.

Responsibilities

• Lead and mentor the Analytical Development team for oligonucleotide and small-molecule programs.
• Develop and validate analytical methods; establish laboratory capabilities.
• Coordinate with CROs/CDMOs and regulatory submissions; supervise external work.

Skills

Analytical development

Chromatography

Mass spectrometry

Oligonucleotide synthesis

Purification

Impurity profiling

Regulatory submissions

CRO/CDMO coordination

Education

Ph.D. in Chemistry or related

M.S. in related field

B.S. in related field

Tools

LC-MS

CRO/CDMO coordination

Job description

Role

Lead and mentor the Oligonucleotide & Small Molecule CMC Analytical Development team, providing scientific leadership in analytical method development, testing, and characterization for biotherapeutics crossing the blood-brain barrier.

Responsibilities

oversee analytical activities for oligonucleotide and small-molecule programs, develop and validate analytical methods, establish laboratory capabilities, troubleshoot technical issues, and collaborate across discovery, process chemistry, quality, and regulatory teams. Manage external analytical work and author key regulatory documentation.

Requirements

Ph.D. in Chemistry, Pharmaceutical Sciences, or related discipline with 7+ years (Ph.D.) or 10+ years (M.S.) or 12+ years (B.S.) industry experience; at least 5 years of hands‑on analytical development supporting oligonucleotide and/or small‑molecule drug substances and products; expertise in chromatographic and mass spectrometry techniques; strong knowledge of oligonucleotide synthesis, purification, and impurity profiling; experience coordinating with CROs/CDMOs and regulatory submissions.

HighValue

biotherapeutics crossing the BBB, oligonucleotide and small‑molecule modalities, analytical development supporting clinical phases, regulatory documentation, GxP laboratory management.

WorkSetup

unspecified; likely on‑site or hybrid based on laboratory leadership role.