Associate Director, Analytical Development

Scorpion Therapeutics; Boston (MA); Hybrid; USD 180,000 - 240,000; Full time

Job summary

Scorpion Therapeutics seeks an Associate Director, Analytical Development to lead in-house lab operations supporting neuromuscular disorder therapies in our pipeline.

Responsibilities include developing and validating analytical methods for peptides, oligonucleotides, and conjugates; overseeing impurity profiling and CQA assessments; and guiding regulatory documentation and interactions with external contract labs. The role emphasizes cross-functional leadership and team mentorship.

Qualifications

• PhD in Chemistry or related field with 5+ years’ experience (PhD) or 8+ years (Master’s).
• Expertise in peptides, oligonucleotides and conjugates.
• Proven leadership in CQA and regulatory submissions.

Responsibilities

• Manage and optimize analytical methods development and validation for peptides, oligos, and conjugates.
• Oversee characterization activities, impurity profiling, and CQA assessments.
• Lead extended characterization, comparability strategies, and regulatory documentation.
• Manage external contract labs.
• Mentor team members and foster cross-functional collaboration.

Skills

Peptides

Oligonucleotides

Conjugates

Analytical method development

Education

PhD in Chemistry or related field

Master’s degree in Chemistry or related field

Tools

UHPLC-TOF

UHPLC-MS/MS

Job description

Role: Associate Director, Analytical Development leading in-house lab operations supporting PepGen's pipeline of neuromuscular disorder therapies.

Responsibilities

• manage and optimize analytical methods development and validation (e.g., UHPLC-TOF, UHPLC-MS/MS) for peptides, oligos, and proprietary enhanced delivery oligonucleotides
• oversee characterization activities, impurity profiling, and CQA assessments
• lead extended characterization, comparability strategies, and regulatory documentation
• manage external contract labs
• mentor team members and foster cross-functional collaboration

Requirements

• Ph.D. in Chemistry or related field with 5+ years’ (Ph.D.) or 8+ years’ (Master’s) experience in analytical development
• expertise in peptides, oligonucleotides, and conjugates
• proven leadership in CQA and regulatory submissions
• strong knowledge of chromatographic techniques, ICH/USP guidelines, cGMPs, and analytical validation

HighValue: biologics/oligos, drug discovery and development, analytical method validation, impurity characterization, regulatory filing support, cross-functional collaboration, team leadership.

WorkSetup: not specified; likely hybrid or onsite with potential for travel.