Senior Scientist

K3-Innovations, Inc.; Worcester (MA); On-site; USD 90,000 - 125,000; Full time

Job summary

K3-Innovations, Inc. in Worcester, MA is seeking a Scientist III to lead analytical characterization of biologics and large molecules, focusing on mass spectrometry/LC-MS and protein characterization. This is a 1-year onsite role.

You will design and execute experiments, troubleshoot analytical challenges, and communicate findings to internal teams and clients. Strong experience in LC-MS, HPLC/UPLC, and PTM analysis is essential.

PhD candidates may be considered; relocation support available.

Qualifications

• Strong hands-on Mass Spectrometry / LC-MS experience.
• Experience with biologics, proteins, or large-molecule characterization.
• Experience with intact protein analysis and/or peptide mapping.
• Understanding of protein structure and PTMs.
• Hands-on HPLC/UPLC experience.
• Ability to independently design, execute, troubleshoot, and interpret experiments.
• Strong scientific documentation and communication skills.
• PhD candidates may be considered.

Responsibilities

• Perform LC-MS analysis of biologics/proteins, including intact/reduced mass analysis and peptide mapping.
• Perform protein characterization, sequence verification, and PTM analysis.
• Conduct HPLC/UPLC separation and fractionation of protein variants.
• Design, execute, and troubleshoot analytical/method-development experiments.
• Generate accurate, reliable, and reproducible analytical data.
• Document experiments and results in ELN.
• Prepare technical reports and communicate findings to internal teams and clients.
• Maintain laboratory equipment and follow laboratory safety and quality procedures.

Skills

Mass Spectrometry

Biologics characterization

Intact protein analysis

PTMs understanding

HPLC/UPLC

Experimental design

Documentation/communication

Education

BS/MS/PhD in Chemistry or Biochemistry or Biology

Tools

ELN

Job description

Scientist III – Analytical Characterization

Location: Worcester, MA | 100% Onsite

Contract: 1 Year + Potential Extension

Relocation: Open to candidates willing to relocate

Interview: Virtual

Positions: 1

Position Summary

We are seeking a Scientist III to support analytical characterization of biologics and large molecules. The primary focus is hands-on mass spectrometry/LC-MS and protein characterization, rather than small-molecule analysis.

The ideal candidate can independently design and execute experiments, troubleshoot analytical challenges, interpret data, and communicate scientific findings.

Key Responsibilities

• Perform LC-MS analysis of biologics/proteins, including intact/reduced mass analysis and peptide mapping.
• Perform protein characterization, sequence verification, and PTM analysis.
• Conduct HPLC/UPLC separation and fractionation of protein variants.
• Design, execute, and troubleshoot analytical/method-development experiments.
• Generate accurate, reliable, and reproducible analytical data.
• Document experiments and results in ELN.
• Prepare technical reports and communicate findings to internal teams and clients.
• Maintain laboratory equipment and follow laboratory safety and quality procedures.

Must-Have Qualifications

• Strong hands-on Mass Spectrometry / LC-MS experience.
• Experience with biologics, proteins, or large-molecule characterization.
• Experience with intact protein analysis and/or peptide mapping.
• Understanding of protein structure and PTMs.
• Hands-on HPLC/UPLC experience.
• Ability to independently design, execute, troubleshoot, and interpret experiments.
• Strong scientific documentation and communication skills.
• BS/MS/PhD in Chemistry, Biochemistry, Biology, or related field.

Preferred

• DSC/biophysical characterization.
• Capillary electrophoresis.
• MS data analysis/bioinformatics.
• IR/NIR/Raman or metabolomics experience.
• Pharmaceutical/biotechnology industry experience.

Important:

Strong biologics-focused Mass Spectrometry/LC-MS experience is the key priority. AKTA, DSC, and other supporting techniques can be trained.

Experience:

Relevant technical expertise is more important than a strict years-of-experience cutoff. PhD candidates may also be considered.