Senior Scientist

Mindlance; Massachusetts; On-site; USD 70,000 - 90,000; Full time

Job summary

Mindlance is seeking a motivated scientist to join the Biologics CMC Developability team in Worcester, MA. This role involves performing in-depth characterization of therapeutic biologics utilizing mass-spectrometry and liquid chromatography techniques.

The ideal candidate will have strong skills in data analysis and documentation, along with a relevant degree and industry experience. The position offers an opportunity to work in a collaborative environment focusing on drug product development.

Qualifications

• 5+ years experience in biopharmaceutical industry with a BS or 2+ years with an MS.
• Hands-on experience with mass-spectrometry and data processing.
• Experience with liquid chromatography for biologic proteins.

Responsibilities

• Perform in-depth LC-MS characterization of therapeutic biologics.
• Conduct liquid chromatography-based characterization of drug candidates.
• Maintain excellent documentation of work and prepare scientific presentations.

Skills

Protein mass-spectrometry

Liquid chromatography methods

Data analysis using MS Excel

Liquid handling robots

Collaborative skills

Education

BS or MS in Biochemistry, Biology, Chemistry

Ph.D. in relevant field

Job description

Contract: 1 year - based on performance and business needs

Job Location: Worcester, MA

Job Overview

The Biologics CMC Developability team is an integral part of the Biologics CMC Drug Product Development Org. The Biologics CMC Developability team is responsible for - (1) the identification of biophysical- and chemical liabilities in discovery-stage biologic drug candidates to guide lead selection, and (2) for characterization of the key CMC attributes important for biologic drug development. We have an exciting opportunity for a motivated scientist to join the Biologics CMC Developability team.

Key Responsibilities

• Perform in-depth LC-MS based characterization of therapeutic biologic molecules and their post-translational modifications.
• Conduct liquid chromatography-based characterization of biologic drug candidates (size exclusion, ion exchange, and reverse phase).
• Execute experimental protocols, collect results, and perform data analysis carefully and independently.
• Maintain excellent documentation of work including electronic lab notebook and protocols.
• Prepare and deliver concise scientific presentations of experimental results.
• Oversee maintenance of key laboratory equipment and routine laboratory operations.
• Build strong relationships with other team members and across groups.
• Understand and adhere to corporate standards regarding code of conduct, safety, and documentation compliance.

Qualifications

• BS or MS in Biochemistry, Biology, Chemistry (or equivalent, e.g., Chemical Engineering, Pharmaceutical Sciences) with 5+ (BS) or 2+ years (MS), or Ph.D. with 0+ years of biopharmaceutical industry experience.
• Hands-on experience with protein mass-spectrometry (subunit analysis, peptide mapping, disulfide mapping) and data processing is required.
• Experience with liquid chromatography methods commonly used for characterization of biologic proteins is required.
• Experience with liquid handling robots and their programming would be highly beneficial.
• Demonstrated track record of independent thinking, creativity, and scientific accomplishment.
• Highly responsible and self-motivated. Skills to plan and conduct experiments with high quality and timely deliverables. Able to perform data analysis using MS Excel & GraphPad.
• Team player with excellent collaboration and communication skills.

EEO

Mindlance is an Equal Opportunity Employer and does not discriminate in employment on the basis of – Minority/Gender/Disability/Religion/LGBTQI/Age/Veterans