Associate Scientist, Biologics Characterization

Scorpion Therapeutics; Lexington (MA); On-site; USD 104,000 - 163,000; Full time

Benefits offered by this job

Medical/dental/vision insurance

401(k) with match

Disability and life insurance

Tuition reimbursement

Paid volunteer time off

Holidays

Well-being benefits

Sick time

Paid vacation

Job summary

Scorpion Therapeutics is seeking an experienced analytical development professional to independently design, execute, and analyze biologics characterization experiments in Lexington, MA. You will apply LC-MS, peptide mapping, intact mass, glycan analysis, and chromatographic methods to assess structure, heterogeneity, purity, stability, and PTMs.

The role requires hands-on lab experience with protein analytics, data interpretation, and strong collaboration across teams to support development,

Qualifications

• Hands-on laboratory experience required.
• Experience with biologics characterization/protein analytical methods.
• Proficient in MS, biophysical characterization, chromatography and electrophoresis.
• Ability to independently execute experiments and communicate conclusions.
• Strong problem-solving, data integrity and cross-functional collaboration.

Responsibilities

• Independently design, plan, execute, analyze, and report biologics characterization experiments under general direction.
• Perform analytical/biophysical studies to assess structure, heterogeneity, purity, stability, degradation pathways, PTMs, HOS, and product-related variants.
• Apply methods such as LC-MS, peptide mapping, intact mass, glycan analysis, HPLC/UPLC, electrophoretic methods, spectroscopy, and thermal analysis.
• Contribute to characterization studies and documentation supporting product/process understanding, comparability, stability, development, tech transfer, and regulatory submissions.
• Prepare protocols, reports, data summaries, method docs; communicate results to internal teams.
• Troubleshoot non-routine method/sample/instrument/data/software/documentation/vendor issues and propose solutions.
• Stay current with analytical technologies and regulatory expectations; may train/mentor others.

Skills

Mass spectrometry

Biophysical characterization

Analytical development

Data analysis

Team collaboration

Education

Associate degree

Bachelor’s degree in related field

Master’s degree in analytical sciences

Tools

LC-MS

Peptide mapping

Intact mass

Glycan analysis

SEC/HPLC/IEX/HIC

icIEF

CE-SDS

AUC

CD/DSC

Job description

Responsibilities:

• Independently design, plan, execute, analyze, and report biologics characterization experiments under general direction.
• Perform analytical/biophysical studies to assess structure, heterogeneity, purity, stability, degradation pathways, post-translational modifications, higher-order structure, and product-related variants.
• Apply/execute methods such as LC-MS, peptide mapping, intact mass, glycan analysis, HPLC/UPLC, electrophoretic methods, spectroscopy, and thermal analysis.
• Contribute to characterization studies and source documentation supporting product/process understanding, comparability, stability, development, technology transfer, and regulatory submissions.
• Prepare protocols, technical reports, data summaries, method documents, and technology transfer documents; communicate results to internal teams.
• Troubleshoot non-routine method/sample/instrument/data/software/documentation/vendor issues and propose solutions.
• Stay current with analytical technologies and regulatory expectations; serve as a technical resource and may train/mentor others.

Qualifications / Skills:

• Associate degree + 7+ years, or Bachelor’s + 5+ years, or Master’s + 3+ years in analytical development/biologics characterization or related fields.
• Required: hands-on laboratory experience.
• Experience with biologics characterization/protein analytical methods and tools such as mass spectrometry, biophysical characterization, chromatography, and electrophoresis.
• Practical knowledge of one or more: LC-MS, peptide mapping, intact mass, glycan analysis, SEC-/RP-/IEX-/HIC-HPLC, icIEF, CE-SDS, AUC, CD, DSC, DLS, fluorescence spectroscopy.
• Ability to independently execute experiments, analyze/interpret data, document, and communicate conclusions.
• Strong problem-solving, data integrity, documentation practices (ELN/LIMS), and cross-functional collaboration.

Benefits (summary):

• Eligible for medical/dental/vision, 401(k) with match, disability and life insurance, tuition reimbursement, paid volunteer time off, holidays, well-being benefits, up to 80 hours sick time, and up to 120 hours paid vacation (new hires).
• U.S. base salary range (Lexington, MA): $103,500–$162,690.