Scientist III

Spectraforce Technologies; Worcester (MA); On-site; USD 110,000 - 140,000; Full time

Job summary

Spectraforce Technologies is seeking a Scientist III for our Worcester, MA site to contribute to Analytical Development. You will develop and execute analytical methods for biologics, including LC-MS and biophysical assays, to support product and process development from discovery through commercial stages.

The ideal candidate will have hands-on experience with protein mass spectrometry, HPLC/AKTA, and a strong understanding of protein structure and post-translational modifications, plus

Qualifications

• Degree and relevant hands-on experience in biotech/pharma.
• Hands-on MS/LC methods and protein characterization experience.
• Fundamental understanding of protein structure and PTMs is required.
• Strong written and verbal communication and organizational skills.

Responsibilities

• Perform MS analyses of biologics to provide sequence verification and PTM profiles.
• Independently perform separation methods using HPLC and AKTA.
• Perform biophysical methods (e.g., DSC) for characterization of biologics.
• Design and execute experiments for method development and investigations.
• Support process development by performing raw material analysis and metabolomics experiments.
• Generate precise, reliable, and reproducible data promptly.
• Organize and document experiments and results in an electronic lab notebook.
• Draft protocols, method development reports, and technical characterization reports.
• Maintain lab equipment and ensure proper operation.

Skills

Separation assays

AKTA

LC-MS analysis

Protein structure knowledge

Communication skills

Education

Bachelor's or Master's degree in chemistry/biology/biochemistry or related discipline

Tools

HPLC instrumentation

AKTA instrumentation

LC-MS

Vibrational spectroscopy

Bioinformatics tools

Job description

Job Title: Scientist III

Duration: 12 months (possible extension)

Location: Worcester, MA, onsite

What are the top 3-5 skills, experience or education required for this position:

• 1.Perform separation assays such as HPLC/UPLC chromatography
• 2.Perform fractionation using AKTA
• 3.Perform LC-MS experiments on intact protein
• 4.Fundamental understanding of protein structure, post-translational modifications, and analytical methods used for protein characterization
• 5. Excellent written communication, oral communication, organization, and multitasking skills

We are searching for a highly motivated Scientist to join our Analytical Development team in Worcester, MA. Our team is responsible for the development, qualification, and execution of analytical methods to provide product and process understanding for biological entities from discovery through commercial stages.

As a Scientist, you will be a part of the Analytical Characterization Group (ACG) within the Analytical Development Department. ACG focuses on providing routine, investigative, and in-depth characterization analyses of biologics to support product and process development for early-phase, late-phase, and commercial programs using liquid chromatography mass spectrometry (LC-MS), spectroscopy and various other biophysical assays.

The successful candidate will contribute to the development and performance of analytical assays and will contribute to the continuous improvement and innovation within ACG and the Analytical Development Department.

Key Responsibilities:

• * Perform mass spectrometry analyses (i.e., intact/reduced mass analysis by LC-MS and peptide mapping by LC-MS) of biologics to provide sequence verification and post-translational modification profiles.
• * Independently perform separation methods (e.g., fractionation & analysis of variants) using HPLC and AKTA
• * Perform biophysical methods (e.g., DSC) of biologics to support characterization studies.
• * Design and execute experiments for method development and/or investigations.
• * Support process development by performing raw material analysis using vibrational spectroscopy and executing metabolomics experiments using mass spectrometry.
• * Generate and communicate precise, reliable, and reproducible data in a timely manner.
• * Organize and document experiments and results in an electronic laboratory notebook.
• * Draft protocols, method development reports, and technical characterization reports.
• * Maintain lab equipment.

Qualifications:

• * Bachelors or Masters in chemistry, biology, biochemistry or related technical discipline with typically 5+ (BS) or 2+ (MS) years of relevant experience in biotech/pharmaceutical industry setting.
• * Hands-on experience with protein mass spectrometry, liquid chromatography, capillary electrophoresis and protein biophysical characterization.
• * Knowledge of HPLC or AKTA instrumentation
• * Fundamental understanding of protein structure, post-translational modifications, and analytical methods used for protein characterization.
• * Working knowledge of bioinformatics tools to process and analyze mass spectrometry data is highly desirable.
• * Knowledge of vibrational spectroscopy (e.g., IR, NIR and Raman) and multivariate analysis is desirable.
• * Proficient with Windows 10 and Microsoft Office (Outlook, Excel, Word, and PowerPoint).
• * Excellent written communication, oral communication, organization, and multitasking skills.
• * Hardworking and motivated to drive both efficiency and quality.
• * Understand and adhere to corporate standards regarding code of conduct, safety, and appropriate handling of materials.