Mass Spectrometry Automation Scientist

Spectraforce Technologies, Inc.; South San Francisco (CA); On-site; USD 140,000 - 190,000; Full time

Job summary

Discovery Biotherapeutics and Genetic Medicine (BGM) at client’s Bay Area site in South San Francisco seeks a Mass Spectrometry Automation Scientist. Hybrid responsibilities include production and analytical characterization of biologics and biopharmaceuticals, with emphasis on automated MS workflows and robust instrument management.

The role combines wet-lab and software automation to advance biologics programs, requiring strong communication and ability to drive decisions through MS data

Qualifications

• BS, MS or PhD in chemistry/biochemistry or related field with 7+ / 5+ / 0+ years of experience.
• Hands-on expertise with MS platforms, e.g., Waters Xevo G2-XS QToF, and MS workflows for protein characterization.
• Proficiency in data processing and bioinformatic workflows (Protein Metrics, Biosphere, Waters Connect, UNIFI).
• Experience applying LC/MS to monoclonal antibodies and biotherapeutics for sequence verification and PTMs.
• Coding experience (Python/R) and developing automated data workflows.

Responsibilities

• Conduct mass spectrometry analyses for comprehensive biologics characterization (intact, reduced, subunit).
• Maintain LC/MS equipment and troubleshoot issues.
• Design and execute production of biotherapeutic proteins with CROs; guide QA attributes and report results.
• Present findings and progress to colleagues and stakeholders.
• Collaborate with MS experts to assess new bioanalytical tech.
• Independently perform lab research and method development with minimal supervision.

Skills

Mass spectrometry

Automation development

Python/R coding

Data analysis

Communication

Instrument maintenance

Team collaboration

Education

BS in chemistry/biochemistry or related

MS in chemistry/biochemistry or related

PhD in chemistry/biochemistry or related

Tools

Waters Xevo G2-XS QToF

Protein Metrics

Biosphere

Waters Connect

UNIFI

Python

R

AKTA purification

Job description

Position Title: Mass Spectrometry Automation Scientist

Length of Contract: Minimum of 1 year

Location/Site: South San Francisco, CA, 94080 - 100% onsite

We are looking for a combination of software automation, analytical instrumentation, and wet-lab experience. The ideal candidate does not need to be an expert in every mass spec platform (experience with Waters Xevo LC/MS instruments and Protein Metrics analytics software is highly desirable) but should be able to understand instrument workflows and build reliable automation around them.

In particular, the hiring manager would like to hear a story or vignettes on how you merged your mass spectrometry expertise and understanding of antibody-based biologics to make critical decisions that drive programs forward.

Job description

Discovery Biotherapeutics and Genetic Medicine (BGM) at client is seeking a highly motivated scientist to join the Biotherapeutics group at the client's Bay Area (ABA) site in South San Francisco. This role offers a unique opportunity to contribute to various Discovery Research Therapeutic Areas (TAs) and projects by providing production and analytical characterization of biologics and biopharmaceutical products, such as monoclonal antibodies, multi-specifics, and other antibody‑like formats. As part of our team, your work will drive the discovery and development of next generation biologics through production and interrogation of protein attributes.

Key responsibilities

• Conduct mass spectrometry analyses for comprehensive characterization of biologics and biotherapeutics, including intact, reduced, and subunit approaches.
• Ensure the optimal functioning of LC/MS equipment through routine maintenance and effective troubleshooting.
• Design and execute production of biotherapeutic proteins to external CRO vendors, provide guidance on desired product quality attributes, then deliver the results of the production to our therapeutic partners.
• Contribute to team discussions, share valuable insights, and present experimental findings and progress updates to colleagues and stakeholders.
• Collaborate with MS experts across our Research & Development Division to assess and implement new bioanalytical technology.
• Independently and autonomously perform laboratory research and method development with minimal supervision, demonstrating high productivity and scientific initiative

Qualifications

• BS, MS, or PhD in chemistry, biochemistry, or related discipline with typically 7+ (BS), 5+ (MS), or 0+ (PhD) years of relevant experience.
• Demonstrated hands‑on expertise with various mass spectrometry platforms, including Waters Xevo G2‑XS QToF, along with proficiency in MS workflows for protein characterization and the use of MS software for analyzing both routine and complex datasets.
• Proficiency in data processing and bioinformatic and statistical workflows (e.g., Protein Metrics, Biosphere, Waters Connect, UNIFI)
• Proven experience in the application of LC/MS analyses for interrogation of monoclonal antibodies, multispecific biologics, and protein therapeutics to provide sequence verification, post‑translational modification, desired/expected chain pairing, and identity of DLP profile.
• Experience with coding/programming (e.g., Python, R, or relevant scripting languages) and in developing automated data workflows or solutions.
• Experience with chromatography and purification systems (protein A/G, AEX, SEC, mixed‑mode with AKTA systems), and analytical instruments (Agilent HPLC, Waters UPLC and LC/MS, CE‑SDS, SDS‑PAGE) is a plus
• Goal‑oriented team player with excellent verbal and written communication skills, a strong positive attitude, and the ability to thrive in a fast‑paced, multidisciplinary environment.