Senior Scientist

Insight Global; King of Prussia (PA); On-site; USD 121,500 - 148,500; Full time

Benefits offered by this job

Comprehensive benefits package

401(k) retirement plan access after 90 days

Paid sick leave and other time off benefits

Job summary

A leading bioprocessing firm is seeking a Senior Scientist in King of Prussia, PA to lead downstream process development for monoclonal antibodies. The role requires strong expertise in chromatography and the ability to manage a small team. Ideal candidates will have a M.S. or Ph.D. with relevant industry experience, and proficiency in analytical techniques. This position offers competitive compensation up to $135,000/year and a comprehensive benefits package starting on day one.

Qualifications

• 8+ years of experience in downstream process development for biologics or 5+ years with a Ph.D.
• Expertise in chromatographic purification of monoclonal antibodies.
• Strong leadership and management skills in a lab environment.

Responsibilities

• Design and execute chromatography-based purification processes for monoclonal antibodies.
• Develop scalable purification processes tailored to client needs.
• Lead technology transfer to external manufacturing sites.

Skills

Preparative chromatography

Antibody purification

Team leadership

Analytical techniques

Education

M.S. in Biochemistry or related field (8 years experience) or Ph.D. (5 years experience)

Tools

AKTA systems

Unicorn software

Tecan Te-Chrom

Job description

Senior Scientist – Downstream Process Development

Job Description

One of our large bioprocessing clients is seeking a Senior Scientist to join their R&D team in King of Prussia, PA. This role is fully on site, 5 days/week and will lead downstream process development efforts focused on the chromatographic purification of monoclonal antibodies. This role is central to our clients mission of enabling large and small biopharmaceutical companies to bring transformative therapies to patients faster and more efficiently. This individual will guide a small team (up to 6 reports) in designing and executing purification strategies that support late‑stage development and manufacturing readiness. The role is 50% hands‑on bioprocess development and 50% people management.

Qualifications

• M.S. in Biochemistry, Chemical Engineering, Biotechnology, or related field with 8 years of relevant industry experience, or Ph.D. with 5 years of experience in downstream process development for biologics.
• Demonstrated expertise in preparative chromatography and antibody purification.
• Proven ability to lead small scientific teams and manage lab operations.

Nice to Have Skills & Experience

• Hands‑on experience with AKTA systems, Unicorn software, and high‑throughput screening platforms (e.g., Tecan Te‑Chrom).
• Proficiency in analytical techniques such as HPLC, SDS‑PAGE, ELISA, UV spectroscopy.
• Familiarity with tech transfer, cGMP/cGLP standards, and regulatory documentation.
• Experience in client‑facing or CDMO environments is a plus.

Responsibilities

• Design, execute, and analyze chromatography‑based purification processes (Protein A, ion exchange, HIC, etc.) for mAbs.
• Develop scalable, robust purification processes tailored to client molecules and manufacturing goals.
• Lead technology transfer activities to external manufacturing sites.
• Author technical reports, protocols, and support regulatory documentation.

Compensation

Up to $135,000/year Base Salary. Exact compensation may vary based on several factors, including skills, experience, and education.

Benefits

Employees in this role will enjoy a comprehensive benefits package starting on day one of employment, including options for medical, dental, and vision insurance. Eligibility to enroll in the 401(k)-retirement plan begins after 90 days of employment. Additionally, employees will have access to paid sick leave and other paid time off benefits as required under applicable law of the worksite location.

Seniority Level

Mid‑Senior level

Employment Type

Full‑time

Job Function

Science

Industries

Pharmaceutical Manufacturing