Scientist / Sr Scientist, Process Development

92Bio, Inc.; Hayward (CA); On-site; USD 110,000 - 180,000; Full time

Job summary

92Bio, Inc. in Hayward, CA is seeking a Scientist / Sr. Scientist to join the Process Development team. The role will be hands-on, purifying and characterizing bispecific and multi-specific antibodies to advance the company's pipeline.

The ideal candidate combines bench-strength in downstream process development with analytical characterization and a track record of partnering with CDMOs to bridge internal development to external manufacturing.

Qualifications

• 2–12 years of industry biologics process development experience.
• Hands-on antibody purification and protein characterization.
• Experience with multispecific antibody formats preferred.

Responsibilities

• Design and optimize purification processes (Protein A, IEX, SEC).
• Assess product quality attributes using multiple analytical techniques.
• Serve as liaison with CDMOs for tech transfer and manufacturing support.
• Prepare SOPs, technical reports, and regulatory documents (IND/IMPD, BLA/MAA modules).
• Support cross-functional development strategy within a lean team.

Skills

Downstream development

Antibody purification

Analytical characterization

CDMO management

Education

Bachelor’s/Master’s/PhD in Biochemistry/Bioengineering/Molecular Biology

Tools

SEC-HPLC

SDS-PAGE

LC-MS

Job description

We are seeking a highly motivated and experienced Scientist / Sr. Scientist to join our Process Development team. In this role, you will serve as a hands-on technical expert for purifying and characterizing bispecific and multi-specific antibodies to advance the company’s pipeline. The ideal candidate combines deep practical expertise in downstream process development and analytical characterization with the ability to partner closely with CDMOs to bridge internal development to external manufacturing.

Key Responsibilities

• Design, execute and drive fit-for-purpose and scale-up purification processes (e.g. Protein A, IEX, SEC etc.) for antibodies and complex biologic formats.
• Evaluate product quality attributes including purity, aggregation, charge heterogeneity and binding activity with a broad range of analytical techniques (e.g. SEC-HPLC, SDS-PAGE, icIEF, Octet, BLI/SPR, MS etc.)
• Serve as technical liaison with CDMO partners — prepare technology transfer materials and support manufacturing runs from a technical standpoint.
• Author and review SOPs, technical reports, development summaries, and regulatory documents (IND/IMPD, BLA/MAA modules).
• Contribute to cross-functional discussions and help shape development strategy with a lean team

Required Qualifications

Education & Experience

• Bachelor’s, Master’s, or PhD in Biochemistry, Bioengineering, Molecular Biology, or related field with 2-12 years of industry biologics process development experience.
• Hands-on experience with antibody purification, and protein characterization — this is a bench-active role.
• Experience with multispecific antibody formats (bispecifics or similar).

Skills & Mindset

• Comfortable working independently and navigating ambiguity in an early-stage environment with evolving priorities.
• Experience working with or managing CDMOs on technical issues, including tech transfer and troubleshooting.
• Strong communicator who can translate bench findings into clear summaries for cross-functional teams.
• Familiarity with IND-enabling development and basic GMP awareness; deep regulatory expertise not required.
• Startup mentality — resourceful, collaborative, and willing to roll up your sleeves.