Senior Purification Scientist — High-Throughput SFC/LC

Jobless; San Diego, Northern (CA, KY); Hybrid; USD 140,000 - 160,000; Full time

Job summary

Satomic in San Diego, CA, seeks an analytical chemist to own and scale the SFC/LC purification fleet, delivering high-throughput, mass-directed purification for drug discovery.

You will develop robust purification methods, maintain and troubleshoot instrumentation, and partner with software teams to automate data flow and reporting.

This hands-on role emphasizes data quality, sample integrity, and building scalable workflows across six preparative systems.

Qualifications

• Ph.D. in Analytical Chemistry, Chemistry, or related field with 4+ years of relevant industry experience.
• Extensive hands-on experience with chromatography-based purification of organic small molecules and high-throughput purification; mass-directed purification strongly preferred.
• Strong experience operating, maintaining, and troubleshooting LC, LC/MS, and SFC/MS instruments.
• Ability to develop generic purification methods that work across diverse small-molecule samples at high throughput.
• Proven ability to work independently and collaboratively in a fast-paced environment.

Responsibilities

• Day-to-day operation of the SFC and reverse-phase LC purification fleet, including method development, run execution, fraction collection strategy, and data review.
• Develop and maintain generic, automation-friendly purification methods that cover the majority of incoming sample types without per-sample tuning.
• Perform preventive maintenance, diagnostics, and troubleshooting across SFC, LC, and LC/MS systems; partner with vendors for service, upgrades, and installations.
• Identify gaps in purification and reformatting workflows to recommend innovations for efficiency and throughput targets.
• Partner with synthetic chemistry to understand sample characteristics upstream and deliver purified material that meets purity and quantity targets downstream.
• Develop materials and protocols for training and mentoring new lab staff on proper use and care of the purification instrumentation and development of chromatography methodologies for SFC and LC purification.

Skills

Analytical chemistry

High-throughput purification

Mass-directed purification

LC-MS & SFC operation

Instrument troubleshooting

Education

Ph.D. in Analytical Chemistry, Chemistry, or related field

M.S. with 6+ years of experience

B.S. with 10+ years of experience

Tools

Analytical Studio

Virscidian

OpenLab

MassLynx

Pipeline Pilot

KNIME

Job description

Satomic in San Diego, CA, seeks an analytical chemist to own and scale the SFC/LC purification fleet, delivering high-throughput, mass-directed purification for drug discovery.

You will develop robust purification methods, maintain and troubleshoot instrumentation, and partner with software teams to automate data flow and reporting.

This hands-on role emphasizes data quality, sample integrity, and building scalable workflows across six preparative systems.