Purification & Analytics Scientist - SFC/LC & HTQC

Iambic

San Diego (CA)

On-site

USD 114,000 - 156,000

Full time

4 days ago
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Benefits offered by this job

Healthcare coverage
401K matching
Flexible spending accounts
Life insurance
Uncapped vacation

Job summary

Iambic Therapeutics seeks an experienced Research Scientist, Purification & Analytical Sciences to advance small-molecule purification and high-throughput analytical capabilities in our San Diego drug discovery team. The role emphasizes SFC-based purification including method development, optimization, and application to diverse chemical matter.

You will collaborate with HTE and medicinal chemistry, delivering purified compounds and high-quality data for AI-driven design–make–test–learn

Qualifications

  • PhD in Chemistry or related field preferred; relevant experience acceptable.
  • Strong hands-on purification expertise in small molecules and method development.
  • Familiarity with preparative SFC and LC, including troubleshooting.

Responsibilities

  • Develop and execute small-molecule purification using SFC and LC.
  • Optimize separations via stationary/mobile phase selection and gradient design.
  • Support high-throughput compound QC using LC/MS and related analytics.
  • Collaborate with medicinal chemistry and HTE teams to deliver purified compounds.
  • Provide hands-on support for SFC, LC, and LC/MS platforms including maintenance.
  • Develop automated and high-throughput workflows integrating sample handling and data management.

Skills

SFC purification
LC purification
High-throughput QC
Chromatography troubleshooting
Automation & data mgmt

Education

PhD in Chemistry or related
MS with 7+ years experience
BS with 9+ years experience

Tools

LC/MS
Analytical instrumentation
Automation platforms

Job description

Iambic Therapeutics seeks an experienced Research Scientist, Purification & Analytical Sciences to advance small-molecule purification and high-throughput analytical capabilities in our San Diego drug discovery team. The role emphasizes SFC-based purification including method development, optimization, and application to diverse chemical matter.

You will collaborate with HTE and medicinal chemistry, delivering purified compounds and high-quality data for AI-driven design–make–test–learn

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