Senior Oligonucleotide Scientist - Process & Purification

Eurofins; Louisville (KY); On-site; USD 110,000 - 150,000; Full time

Benefits offered by this job

Medical, dental, vision insurance

Life and disability insurance

401(k) with company match

Paid vacation and holidays

Job summary

Eurofins USA Genomic Services is seeking an experienced Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing. This role focuses on developing, optimizing, and scaling chemical processes for high-throughput and high-quality oligonucleotide production.

Responsibilities include designing and scaling synthesis, improving purification methods, and ensuring quality system compliance, with mentorship of lab technicians.

Qualifications

• Ph.D. or Master’s degree in Organic Chemistry or related field is required.
• Minimum 5 years of industrial chemical synthesis experience.
• Hands-on experience with solid-phase oligonucleotide synthesis.
• Experience scaling processes to manufacturing and GMP environments.
• Familiarity with automated DNA/RNA synthesizers and modified nucleotides is preferred.

Responsibilities

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides.
• Process development and scale-up from R&D to manufacturing.
• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting).
• Troubleshoot synthesis and purification challenges to improve yield and purity.
• Collaborate with manufacturing, QC, and engineering for process transfer.
• Evaluate new chemistries and technologies.
• Author SOPs, batch records, and technical reports.
• Ensure compliance with quality systems.
• Mentor lab technicians.

Skills

Oligonucleotide synthesis

Purification processes

Process development

Scale-up

Analytical skills

Mentoring

Education

Ph.D. in Organic Chemistry

Master’s degree in Organic Chemistry

Tools

HPLC

LC-MS

Automated DNA/RNA synthesizers

GMP systems

Oligonucleotide purification platforms

Job description

Eurofins USA Genomic Services is seeking an experienced Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing. This role focuses on developing, optimizing, and scaling chemical processes for high-throughput and high-quality oligonucleotide production.

Responsibilities include designing and scaling synthesis, improving purification methods, and ensuring quality system compliance, with mentorship of lab technicians.