Senior Oligonucleotide Process Scientist

Eurofins US Network; Louisville (KY); On-site; USD 90,000 - 130,000; Full time

Benefits offered by this job

Medical, dental, vision

401(k) with company match

Paid vacation and holidays

Life and disability insurance

Job summary

Eurofins USA Genomic Services in Louisville, KY, seeks an experienced Organic Chemist specialized in oligonucleotide synthesis to support process development and manufacturing. The role focuses on developing, optimizing, and scaling chemical processes for high-throughput oligo production.

The candidate should have 5+ years in chemical synthesis, hands-on solid-phase oligonucleotide work, and proficiency in HPLC/LC-MS, with GMP exposure preferred. Regular hours with potential overtime are offered.

Qualifications

• Ph.D. or Master’s in Organic Chemistry or related field.
• Minimum 5 years of industrial experience in chemical synthesis.
• Hands-on experience with solid-phase oligonucleotide synthesis.
• Hands-on experience in oligonucleotide purification process development.
• Strong analytical skills (HPLC, LC-MS).
• Experience scaling processes to manufacturing.
• Experience in GMP or regulated environments is preferred.

Responsibilities

• Design, develop, and optimize synthesis processes for nucleotides and oligonucleotides.
• Process development and scale-up from R&D to manufacturing.
• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting).
• Troubleshoot synthesis and purification challenges to improve yield and purity.
• Collaborate with manufacturing, QC, and engineering for process transfer.
• Evaluate new chemistries and technologies.
• Author SOPs, batch records, and technical reports.
• Ensure compliance with quality systems.
• Mentor lab technicians.

Skills

Oligonucleotide synthesis

HPLC

LC-MS

Process development

GMP experience

Automation familiarity

Education

Ph.D. in Organic Chemistry

M.S. in Organic Chemistry

Tools

Automated DNA synthesizers

HPLC systems

LC-MS instruments

Job description

Eurofins USA Genomic Services in Louisville, KY, seeks an experienced Organic Chemist specialized in oligonucleotide synthesis to support process development and manufacturing. The role focuses on developing, optimizing, and scaling chemical processes for high-throughput oligo production.

The candidate should have 5+ years in chemical synthesis, hands-on solid-phase oligonucleotide work, and proficiency in HPLC/LC-MS, with GMP exposure preferred. Regular hours with potential overtime are offered.