Senior Scientist - Oligonucleotide Synthesis & Purification

Eurofins; Louisville (KY); Hybrid; USD 120,000 - 180,000; Full time

Benefits offered by this job

Medical benefits

Dental and vision options

401(k) with company match

Paid vacation and holidays

Job summary

Eurofins USA Genomic Services is seeking a highly skilled Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing. The role focuses on developing, optimizing, and scaling chemical processes for high-throughput oligonucleotide production.

The ideal candidate has 5+ years in chemical synthesis, hands-on oligo synthesis, and purification development, with strong analytical skills (HPLC, LC-MS) and GMP exposure.

Qualifications

• Ph.D. or Master’s degree in Organic Chemistry or related field (required).
• Minimum 5 years of industrial experience in chemical synthesis.
• Hands-on experience with solid-phase oligonucleotide synthesis.
• Hands-on experience in oligonucleotide purification process development.
• Strong analytical skills (HPLC, LC-MS).
• Experience scaling processes to manufacturing; GMP or regulated environments preferred.

Responsibilities

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides.
• Process development and scale-up from R&D to manufacturing.
• Develop and improve oligonucleotide purification processes (HPLC, ion-exchange, desalting).
• Troubleshoot synthesis and purification challenges to improve yield and purity.
• Collaborate with manufacturing, QC, and engineering for process transfer.
• Evaluate new chemistries and technologies; write SOPs, batch records, and reports.
• Ensure compliance with quality systems.

Skills

Chemical synthesis

Oligonucleotide purification

Analytical skills

Process development

Technology transfer

Education

Ph.D. or Master’s degree in Organic Chemistry or related field

Tools

HPLC

LC-MS

Solid-phase oligonucleotide synthesizers

Automated DNA/RNA synthesizers

Job description

Eurofins USA Genomic Services is seeking a highly skilled Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing. The role focuses on developing, optimizing, and scaling chemical processes for high-throughput oligonucleotide production.

The ideal candidate has 5+ years in chemical synthesis, hands-on oligo synthesis, and purification development, with strong analytical skills (HPLC, LC-MS) and GMP exposure.