Lead Purification Scientist – Oligos & Peptides (Process Development)

SGS Consulting; Boston (MA); On-site; USD 75,000 - 120,000; Full time

Job summary

SGS Consulting is seeking an Associate Scientist to develop and characterize purification processes for a growing pipeline of oligonucleotide and peptide therapies. You will use various chromatography modes and UF/DF, learn chemical steps, and explore new technologies to enhance purity and productivity.

The role requires documenting work, mentoring staff, and leading pilot-scale activities, with opportunities for tech transfer to GMP facilities and participation in IND regulatory sections.

Qualifications

• Proven track record of planning and executing projects and experiments.
• Demonstrated ability to document laboratory work in development reports, and to mentor others.
• Experience with protein, peptide or DNA/RNA purification using Ion Exchange, Hydrophobic Interaction, or Reversed-Phase chromatography.
• UF/DF experience for scalable processes.
• Strong organizational, communication, and time management skills.
• Ability to work independently and in cross-functional teams.

Responsibilities

• Develop and characterize purification processes for oligonucleotides and peptide drug therapies.
• Use chromatography, ultrafiltration, and learn cleavage/conjugation/hybridization steps.
• Investigate new purification technologies to improve purity, robustness, and productivity.
• Collaborate cross-functionally to improve process understanding and manage activities.
• Document laboratory work in development reports.
• Train and mentor new employees.
• Lead pilot scale activities and scale-up to GMP facilities.
• Participate in tech transfer and regulatory sections for INDs.
• Conduct purification development including process characterization and scale-up.
• Contribute to tech transfer documentation, manufacturing support, and troubleshooting.
• Carry out robustness studies and early/late-stage characterization.
• Serve as SME for purification and coordinate with Research, Manufacturing, and tech transfer teams.
• Write development reports and lead small initiatives.
• Perform independent root cause investigations with supervisor guidance.

Skills

Project planning & execution

Written & verbal communication

Purification tech development

Chromatography knowledge

UF/DF experience

Protein/peptide/DNA/RNA analysis

AKTA/Unicorn experience

DoE statistical methods

Team collaboration

Education

Bachelor’s in Biochemistry/Chemical Eng/Chemistry or life sciences

Master’s degree (optional)

Industry experience 2–4 years (Assoc Scientist 3/Engineer 2)

US work authorization (citizen/green card)

Tools

AKTA purification systems

Unicorn software

Job description

SGS Consulting is seeking an Associate Scientist to develop and characterize purification processes for a growing pipeline of oligonucleotide and peptide therapies. You will use various chromatography modes and UF/DF, learn chemical steps, and explore new technologies to enhance purity and productivity.

The role requires documenting work, mentoring staff, and leading pilot-scale activities, with opportunities for tech transfer to GMP facilities and participation in IND regulatory sections.