Senior Oligonucleotide Scientist - Process Development

Eurofins Genomics Americas; Louisville (KY); On-site; USD 110,000 - 160,000; Full time

Benefits offered by this job

Healthcare benefits including medical

Dental and vision coverage

Life and disability insurance

401(k) with company match

Paid vacation and holidays

Job summary

Eurofins USA Genomic Services seeks an experienced Organic Chemist with expertise in oligonucleotide synthesis and purification to advance process development and manufacturing. You will design and optimize chemical synthesis for nucleotides, scale processes from R&D to production, and mentor lab staff.

The role requires 5+ years in industry, familiarity with DNA/RNA synthesizers, and strong analytical skills (HPLC, LC-MS). Commutable to Louisville, KY, with full benefits and Monday–Friday hours.

Qualifications

• Ph.D. or Master’s degree in Organic Chemistry or related field (required).
• Minimum 5 years of industrial experience in chemical synthesis.
• Hands-on experience with solid-phase oligonucleotide synthesis.
• Hands-on experience in oligonucleotide purification process development.
• Strong analytical skills (HPLC, LC-MS).
• Experience scaling processes to manufacturing.
• GMP or regulated environments preferred.
• Familiarity with automated DNA/RNA synthesizers strongly preferred.
• Knowledge of modified nucleotides strongly preferred.
• Experience in high-throughput oligo production strongly preferred.
• Authorization to work in the United States indefinitely without restriction or sponsorship.

Responsibilities

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides.
• Process development and scale-up from R&D to manufacturing.
• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting).
• Troubleshoot synthesis and purification challenges to improve yield and purity.
• Collaborate with manufacturing, QC, and engineering for process transfer.
• Evaluate new chemistries and technologies.
• Author SOPs, batch records, and technical reports.
• Ensure compliance with quality systems.
• Mentor lab technicians.

Skills

Industrial experience

Oligonucleotide synthesis

Oligonucleotide purification

HPLC

LC-MS

Process scale-up

Automated DNA/RNA synthesizers

Modified nucleotides

Education

Ph.D. or Master’s degree in Organic Chemistry or related field

Job description

Eurofins USA Genomic Services seeks an experienced Organic Chemist with expertise in oligonucleotide synthesis and purification to advance process development and manufacturing. You will design and optimize chemical synthesis for nucleotides, scale processes from R&D to production, and mentor lab staff.

The role requires 5+ years in industry, familiarity with DNA/RNA synthesizers, and strong analytical skills (HPLC, LC-MS). Commutable to Louisville, KY, with full benefits and Monday–Friday hours.