Senior Oligonucleotide Scientist — Process Development

Eurofins; Louisville, Northern (KY, KY); Hybrid; USD 90,000 - 150,000; Full time

Benefits offered by this job

Medical benefits

Dental coverage

Vision coverage

Life insurance

Disability insurance

401(k) with company match

Paid vacation

Holidays

Job summary

Eurofins USA Genomic Services in Louisville, KY, is seeking a highly skilled Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing.

This role focuses on developing, optimizing, and scaling chemical processes for high-throughput oligonucleotide production, including purification by HPLC and ion-exchange, troubleshooting, and contributing to SOPs and batch records within a GMP environment.

Qualifications

• Ph.D. or Master’s degree in Organic Chemistry or related field (required).
• Minimum 5 years of industrial experience in chemical synthesis.
• Hands-on experience with solid-phase oligonucleotide synthesis.
• Hands-on experience in oligonucleotide purification process development.
• Strong analytical skills (HPLC, LC-MS).
• Experience scaling processes to manufacturing.
• Experience in GMP or regulated environments preferred.
• Authorization to work in the United States indefinitely without restriction or sponsorship.

Responsibilities

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides.
• Process development and scale-up from R&D to manufacturing.
• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting).
• Troubleshoot synthesis and purification challenges to improve yield and purity.
• Collaborate with manufacturing, QC, and engineering for process transfer.
• Evaluate new chemistries and technologies.
• Author SOPs, batch records, and technical reports.
• Ensure compliance with quality systems.

Skills

Solid-phase oligonucleotide synthesis

Oligonucleotide purification

HPLC

LC-MS

Process scale-up

GMP

Automated DNA/RNA synthesizers

Modified nucleotides

High-throughput oligo production

Education

Ph.D. in Organic Chemistry

Tools

HPLC

LC-MS

Automated DNA/RNA synthesizers

Job description

Eurofins USA Genomic Services in Louisville, KY, is seeking a highly skilled Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing.

This role focuses on developing, optimizing, and scaling chemical processes for high-throughput oligonucleotide production, including purification by HPLC and ion-exchange, troubleshooting, and contributing to SOPs and batch records within a GMP environment.