Oligonucleotide Process Development Scientist

Eurofins Genomics Americas; Louisville (KY); On-site; USD 120,000 - 160,000; Full time

Benefits offered by this job

Medical, dental, and vision coverage

Life and disability insurance

401(k) with company match

Paid vacation and holidays

Job summary

Eurofins USA Genomic Services is seeking a highly skilled Organic Chemist for process development of nucleotide and oligonucleotide synthesis. This role focuses on scaling chemical processes from R&D to manufacturing and ensuring high purity via purification methods.

The candidate should have 5+ years in chemical synthesis, hands-on oligonucleotide work, and a track record in GMP settings, with familiarity in automated synthesizers and modified nucleotides. Louisville area preferred.

Qualifications

• Ph.D. or Master’s degree in Organic Chemistry or related field (required)
• Minimum 5 years of industrial experience in chemical synthesis
• Hands-on experience with solid-phase oligonucleotide synthesis
• Hands-on experience in oligonucleotide purification process development
• Strong analytical skills (HPLC, LC-MS)
• Experience scaling processes to manufacturing
• Experience in GMP or regulated environments, preferred
• Familiarity with automated DNA/RNA synthesizers, strongly preferred
• Knowledge of modified nucleotides, strongly preferred
• Experience in high-throughput oligo production, strongly preferred
• Authorization to work in the United States indefinitely without restriction or sponsorship.

Responsibilities

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides
• Process development and scale-up from R&D to manufacturing
• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting)
• Troubleshoot synthesis and purification challenges to improve yield and purity
• Collaborate with manufacturing, QC, and engineering for process transfer
• Evaluate new chemistries and technologies
• Author SOPs, batch records, and technical reports
• Ensure compliance with quality systems
• Mentor lab technicians

Skills

Oligonucleotide synthesis

Oligonucleotide purification

GMP experience

Chemical synthesis

Analytical techniques (HPLC LC-MS)

High-throughput oligo production

Automated DNA/RNA synthesizers

Education

Ph.D. in Organic Chemistry

Master’s in Organic Chemistry

Tools

Automated DNA/RNA synthesizers

Job description

Eurofins USA Genomic Services is seeking a highly skilled Organic Chemist for process development of nucleotide and oligonucleotide synthesis. This role focuses on scaling chemical processes from R&D to manufacturing and ensuring high purity via purification methods.

The candidate should have 5+ years in chemical synthesis, hands-on oligonucleotide work, and a track record in GMP settings, with familiarity in automated synthesizers and modified nucleotides. Louisville area preferred.