Synthetic DNA Process Development Scientist

Eurofins US Network; Louisville (KY); On-site; USD 95,000 - 130,000; Full time

Job summary

Eurofins US Network in Louisville, KY is seeking an Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing. Develop, optimize, and scale chemical processes for high-throughput oligonucleotide production.

Ph.D. or Master’s in Organic Chemistry and 5+ years of industrial synthesis experience required; strong HPLC/LC-MS skills and experience with scale-up to manufacturing are essential.

Qualifications

• Ph.D. or Master’s degree in Organic Chemistry or related field (required).
• Minimum 5 years of industrial experience in chemical synthesis.
• Experience with solid-phase oligonucleotide synthesis.
• Experience in oligonucleotide purification process development.
• Strong analytical skills (HPLC, LC-MS).
• Experience scaling processes to manufacturing.

Responsibilities

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides.
• Process development and scale-up from R&D to manufacturing.
• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting).
• Troubleshoot synthesis and purification challenges to improve yield and purity.
• Collaborate with manufacturing, QC, and engineering for process transfer.
• Evaluate new chemistries and technologies.
• Author SOPs, batch records, and technical reports.
• Ensure compliance with quality systems.
• Mentor lab technicians.

Skills

Oligonucleotide synthesis

Process development

Scale-up to manufacturing

Analytical skills

Education

PhD in Organic Chemistry

Master's degree in Organic Chemistry

Tools

HPLC

LC-MS

Job description

Louisville, KY, USA

Full-time

Company Description

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate. Eurofins is the global leader in food, environment, pharmaceutical and cosmetic product testing and in agroscience Contract Research Organisation services. Eurofins is one of the market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, advanced material sciences and in the support of clinical studies, as well as having an emerging global presence in Contract Development and Manufacturing Organisations. The Group also has a rapidly developing presence in highly specialised and molecular clinical diagnostic testing and in-vitro diagnostic products. In over just 30 years, Eurofins has grown from one laboratory in Nantes, France to 55,000 staff across a decentralised and entrepreneurial network of 900 laboratories in over 50 countries. Eurofins offers a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products.

Job Description

Position Summary

We are seeking a highly skilled and motivated Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing. This role focuses on developing, optimizing, and scaling chemical processes for high-throughput and high-quality oligonucleotide production.

Key Responsibilities

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides
• Process development and scale-up from R&D to manufacturing
• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting)
• Troubleshoot synthesis and purification challenges to improve yield and purity
• Collaborate with manufacturing, QC, and engineering for process transfer
• Evaluate new chemistries and technologies
• Author SOPs, batch records, and technical reports
• Ensure compliance with quality systems
• Mentor lab technicians

Qualifications

• Ph.D. or Master’s degree in Organic Chemistry or related field (required)
• Minimum 5 years of industrial experience in chemical synthesis
• Experience with solid‑phase oligonucleotide synthesis
• Experience in oligonucleotide purification process development
• Strong analytical skills (HPLC, LC-MS)
• Experience scaling processes to manufacturing

Preferred Qualifications

• Experience in GMP or regulated environments
• Familiarity with automated DNA/RNA synthesizers
• Knowledge of modified nucleotides
• Experience in high‑throughput oligo production

Work Environment

• Fast‑paced, collaborative environment
• Ability to manage multiple priorities
• Occasional off‑hours support as needed

Work Schedule

Location: Louisville, KY

Schedule: Monday-Friday, 8:00 AM - 5:00 PM

Weekend Work as needed

Additional Information

All your information will be kept confidential according to EEO guidelines.