Oligonucleotide Senior Scientist

Eurofins US Network; Louisville (KY); On-site; USD 90,000 - 130,000; Full time

Benefits offered by this job

Medical, dental, vision

401(k) with company match

Paid vacation and holidays

Life and disability insurance

Job summary

Eurofins USA Genomic Services in Louisville, KY, seeks an experienced Organic Chemist specialized in oligonucleotide synthesis to support process development and manufacturing. The role focuses on developing, optimizing, and scaling chemical processes for high-throughput oligo production.

The candidate should have 5+ years in chemical synthesis, hands-on solid-phase oligonucleotide work, and proficiency in HPLC/LC-MS, with GMP exposure preferred. Regular hours with potential overtime are offered.

Qualifications

• Ph.D. or Master’s in Organic Chemistry or related field.
• Minimum 5 years of industrial experience in chemical synthesis.
• Hands-on experience with solid-phase oligonucleotide synthesis.
• Hands-on experience in oligonucleotide purification process development.
• Strong analytical skills (HPLC, LC-MS).
• Experience scaling processes to manufacturing.
• Experience in GMP or regulated environments is preferred.

Responsibilities

• Design, develop, and optimize synthesis processes for nucleotides and oligonucleotides.
• Process development and scale-up from R&D to manufacturing.
• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting).
• Troubleshoot synthesis and purification challenges to improve yield and purity.
• Collaborate with manufacturing, QC, and engineering for process transfer.
• Evaluate new chemistries and technologies.
• Author SOPs, batch records, and technical reports.
• Ensure compliance with quality systems.
• Mentor lab technicians.

Skills

Oligonucleotide synthesis

HPLC

LC-MS

Process development

GMP experience

Automation familiarity

Education

Ph.D. in Organic Chemistry

M.S. in Organic Chemistry

Tools

Automated DNA synthesizers

HPLC systems

LC-MS instruments

Job description

Louisville, KY, USA

Full-time

Company Description

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate.

Eurofins is the global leader in food, environment, pharmaceutical and cosmetic product testing and in agroscience Contract Research Organisation services. Eurofins is one of the market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, advanced material sciences and in the support of clinical studies, as well as having an emerging global presence in Contract Development and Manufacturing Organisations. The Group also has a rapidly developing presence in highly specialised and molecular clinical diagnostic testing and in-vitro diagnostic products.

In over just 30 years, Eurofins has grown from one laboratory in Nantes, France to 55,000 staff across a decentralised and entrepreneurial network of 900 laboratories in over 50 countries. Eurofins offers a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products.

Job Description

Oligonucleotide Senior Scientist Include but are not Limited to the Following:

We are seeking a highly skilled and motivated Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing. This role focuses on developing, optimizing, and scaling chemical processes for high-throughput and high-quality oligonucleotide production.

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides

• Process development and scale-up from R&D to manufacturing

• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting)

• Troubleshoot synthesis and purification challenges to improve yield and purity

• Collaborate with manufacturing, QC, and engineering for process transfer

• Evaluate new chemistries and technologies

• Author SOPs, batch records, and technical reports

• Ensure compliance with quality systems

• Mentor lab technicians

Qualifications

Basic Minimum Education Qualifications :

• Ph.D. or Master’s degree in Organic Chemistry or related field (required)

Basic Minimum Work Requirements :

• Minimum 5 years of industrial experience in chemical synthesis

• Hands-on experience with solid-phase oligonucleotide synthesis

• Hands-on experience in oligonucleotide purification process development

• Strong analytical skills (HPLC, LC-MS)

• Experience scaling processes to manufacturing

• Experience in GMP or regulated environments, preferred

• Familiarity with automated DNA/RNA synthesizers, strongly preferred

• Knowledge of modified nucleotides, strongly preferred

• Experience in high-throughput oligo production, strongly preferred

• Authorization to work in the United States indefinitely without restriction or sponsorship.

The Ideal Candidates Possess the Following:

• Fast-paced, collaborative environment

• Ability to manage multiple priorities

• Occasional off-hours support as needed

Additional Information

Position is full-time working Monday – Friday 8:00am – 5:00pm, with overtime and weekend work as needed. Candidates currently living within a commutable distance of Louisville, KY are encouraged to apply.

• Excellent full-time benefits including comprehensive medical coverage, dental, and vision options

• Life and disability insurance

• 401(k) with company match

• Paid vacation and holidays

LI-KS1

Eurofins USA Genomic Services is a Disabled and Veteran Equal Employment Opportunity employer.