Senior Oligo Chemistry Scientist - On-Site, LC-MS Expert

Integrated DNA Technologies; Sunnyvale (CA); On-site; USD 135,000 - 160,000; Full time

Benefits offered by this job

Paid time off

Medical/dental/vision insurance

401(k)

Job summary

Integrated DNA Technologies (IDT), a Danaher operating company in Sunnyvale, CA, seeks a Senior Scientist, Oligo Chemistry to contribute hands-on expertise to synthesis development, optimization, and characterization.

You will design and optimize phosphoramidite‑based workflows, apply organic chemistry to improve yield and product quality, and use high‑resolution LC‑MS to verify oligo integrity and troubleshoot issues.

Qualifications

• Bachelor’s degree in chemistry, organic chemistry, biochemistry, or related discipline; advanced degree preferred.
• Minimum of 5+ years of hands‑on laboratory experience in oligonucleotide synthesis or closely related chemistry
• Strong practical expertise in phosphoramidite chemistry and solid‑phase oligo synthesis
• Demonstrated experience using LC‑MS (high‑resolution preferred) to characterize oligos and diagnose synthesis or process issues
• Proven experience optimizing synthesis or downstream process steps, including cleavage, deprotection, and purification.

Responsibilities

• Design, execute, and optimize oligonucleotide synthesis workflows with a strong focus on phosphoramidite chemistry and solid‑phase synthesis
• Apply organic chemistry principles to improve synthesis efficiency, yield, and product quality
• Develop and optimize post‑synthesis process steps, including cleavage, deprotection, and purification (e.g., cartridge, HPLC, or other relevant methods), utilizing high‑resolution mass spectrometry (LC‑MS) and complementary analytical techniques to assess oligo identity, purity, and failure modes
• Contribute to evaluation and implementation of new reagents, chemistries, or process improvements for oligo synthesis platforms
• Other duties as assigned.

Skills

Oligonucleotide synthesis

Phosphoramidite chemistry

Solid‑phase synthesis

LC‑MS (HRMS)

Organic chemistry

Synthesis optimization

Laboratory safety

Education

Bachelor's degree in chemistry

MS or PhD preferred

Tools

LC‑MS instrumentation

Job description

Integrated DNA Technologies (IDT), a Danaher operating company in Sunnyvale, CA, seeks a Senior Scientist, Oligo Chemistry to contribute hands-on expertise to synthesis development, optimization, and characterization.

You will design and optimize phosphoramidite‑based workflows, apply organic chemistry to improve yield and product quality, and use high‑resolution LC‑MS to verify oligo integrity and troubleshoot issues.