Scientist-oligonucleotide

Integrated Resources, Inc ( IRI ); Cambridge (MA); On-site; USD 55,000 - 75,000; Full time

Job summary

Integrated Resources, Inc (IRI) is looking for a lab technician in Cambridge, MA, to support oligonucleotide synthesis and analytical testing. The candidate will be responsible for hands-on lab support in oligonucleotide-based drug substance production, including synthesis and downstream processing, along with in-process analytical testing such as HPLC and LCMS. A BS in Chemistry and 3+ years of lab experience are required, with a strong focus on communication and teamwork in a dynamic environment.

Qualifications

• BS in Chemistry with 3+ years lab experience, preferably in an industrial setting.
• Basic understanding of analytical techniques such as pH and HPLC.
• Experience in record-keeping and excellent laboratory documentation practice.
• Good communication skills are essential.

Responsibilities

• Hands-on lab support and process development for oligonucleotide-based drug substance.
• Synthesis of oligonucleotides up to 11 mmol scale.
• Perform in-process analytical testing including AX-HPLC and LCMS.

Skills

Oligonucleotide synthesis

Analytical techniques

Laboratory documentation

Communication skills

Education

BS in Chemistry

Tools

HPLC

LCMS

UV-vis

Job description

Skill set – Oligonucleotide synthesis and downstream processing, Analytical HPLC/LCMS/UV-vis

• Hands‑on lab support and process development for the chemical synthesis and downstream processing of oligonucleotide‑based drug substance
• Synthesis of oligonucleotides up to 11 mmol scale
• Downstream processing of oligonucleotides including prep‑HPLC, Ultrafiltration, annealing, concentration and Lyophilization
• In‑process analytical testing including AX‑HPLC, IPRP‑HPLC, LCMS, UV‑vis
• Technical support for optimization of contract manufacturing processes

Qualifications

• BS in Chemistry with 3+ years lab experience, preferably in an industrial setting.
• Basic understanding of analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC‑MS etc.). Related hands‑on experience is preferred. Knowledge of oligonucleotide manufacture process including phosphoramidite chemistry, chromatography, ultrafiltration etc. is a plus.
• Experience in record‑keeping and excellent laboratory documentation practice, are required. Strong commitment to high laboratory and scientific standard; ability to maintain a safe, clean, and orderly laboratory work environment; assist in routine lab and equipment maintenance.
• Good communication skills are a must for this position. The successful candidate must be a responsible and proactive individual who is able to work as a team player in a highly dynamic environment with aggressive timelines.