Senior MSL - Field-Based TRD/PTSD Neuroscience

Compass Pathways, Inc.; Philadelphia (Philadelphia County); Hybrid; USD 140,000 - 190,000; Full time

Job summary

Compass Pathways, Inc. is seeking an (Senior) Medical Science Liaison in the Philadelphia region to connect our science with the mental health community, shaping medical strategy and supporting TRD and PTSD programs.

This field-based role emphasizes high-quality scientific exchange with healthcare professionals and researchers in neuroscience. The candidate will manage a geographic territory, travel as needed, and collaborate with Clinical Development and other teams.

Qualifications

• Previous Medical Science Liaison experience preferred.
• Strong ability to communicate complex scientific concepts clearly.
• Ability to manage relationships with key opinion leaders and stakeholders.

Responsibilities

• Develop and maintain scientific relationships with HCPs and thought leaders in neuroscience and mental health.
• Lead compliant scientific discussions on disease understanding and emerging evidence for TRD and PTSD.
• Respond to unsolicited questions with accurate medical information.
• Collect and communicate field insights to inform clinical development and strategy.
• Maintain high scientific expertise in cognitive disorders and competing therapies.
• Support medical education initiatives and advisory boards.

Skills

MSL experience

Scientific communication

Stakeholder management

Travel readiness

Education

PhD/MD/PharmD/PMHNP

Job description

(Senior) Medical Science Liaison - Philadelphia, PA

United States

Company introduction:

Compass Pathways plc (Nasdaq: CMPS) is a biotechnology companydedicatedto unlocking urgently needed new treatment options in mental health care.

The Company is headquartered in London, UK, with a U.S. office in New Jersey. We believe mental health patients deserve the possibility of a better future. Our initial focus is developing COMP360 psilocybin, a proprietary, investigational, synthetic psilocybin treatment under evaluation for treatment-resistant depression (TRD) and post-traumatic stress disorder (PTSD). COMP360 is a potentially first-in-class treatment and has Breakthrough Therapy designation from the U.S. Food and Drug Administration (FDA), as well as Innovative Licensing and Access Pathway (ILAP) designation in the UK for TRD.

We are leading the world’s largest classic psychedelic clinical program in TRD, and building upon that robust foundation, we are executing a late-stage trial evaluating COMP360 for PTSD, another condition with high unmet need. Our goal is to advance treatments that move the field of psychiatry towards treatment options that offer rapid onset and sustained durability with infrequent dosing. - Compass Pathways

Job overview:

The Medical Science Liaison (MSL) / Senior Medical Science Liaison (Sr. MSL) at Compass Pathways is a core member of the Medical Affairs organization, connecting the company’s science with the broader mental health and neuroscience community, helping to shape medical strategy, and supporting the continued development of Compass Pathways’ work in treatment-resistant depression (TRD) and post-traumatic stress disorder (PTSD).

This role is responsible for developing and managing a geographic territory and serving as a key scientific point of contact through both virtual and face-to-face interactions. The ideal candidate is passionate about a field-based role establishing themselves as a key point of scientific contact, actively engaging in high-quality scientific exchange and gathering insights from the field on emerging research, changes in the treatment landscape, and evolving approaches to care.

Location: Field based in Philadelphia, PA; Washington, DC; Baltimore, MD or Newark, NJ.

Reports to: Director, Medical Science Liaison.

Roles and responsibilities
(include but are not limited to):

• Develop and maintain scientifically grounded relationships with healthcare professionals, researchers, and thought leaders across neuroscience and mental healthcare within the assigned territory
• Lead in-depth, compliant scientific conversations focused on disease understanding, research methodology, and emerging evidence in treatment-resistant depression and PTSD
• Anticipate and address scientific questions from external stakeholders by providing accurate, balanced medical information in response to unsolicited requests
• Collect, analyze, and communicate medical insights from the field to internal stakeholders to inform clinical development, medical strategy, and educational planning
• Maintain a high level of scientific expertise in relevant therapeutic areas, competitive landscape, and emerging research through continuous -- sometimes self-guided -- learning
• Contribute to the planning and execution of medical education activities, advisory boards, and scientific congress engagements and presentations
• Uphold all ethical, regulatory, and compliance requirements in the conduct of field medical activities
• Collaborate cross-functionally with internal partners (e.g., Clinical Development, Government Affairs, Market Access)
• Provide training to eventual sales and marketing teams
• For Senior MSLs: mentor and coach junior MSLs, support onboarding and training efforts, and contribute to broader medical affairs initiatives or special projects

Candidateprofile:

• Advanced scientific training with associated credentials (e.g., PhD, PharmD, PMHNP, MD)
• Previous MSL experience is strongly preferred
• Preference for candidates with background/experience in neuroscience, psychiatry or psychology
• Ability to travel up to 75%, including overnight stays and weekends, as needed
• Candidate must reside within the geographic area
• Engaging and expert communicator of scientific information and representing core values to a diverse array of audiences
• Excellent verbal and written communication, listening skills, and emotional intelligence
• Proven experience of self-motivation, accountability, integrity & teamwork
• Passion for improving and transforming mental health – full alignment with Compass' values

Compensation Description (annually):

Our compensation package for permanent hires includes base salary, discretionary bonus, and equity, alongside our comprehensive benefits offering.

Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, and work location.

These include f lexibility & generous time off, parental & reproductive support, health & medical, mental health & wellbeing and Financial health.

Equal opportunities:

Reasonable accommodation

We are committed to building a workplace where everyone’s wellbeing matters. If you need reasonable accommodation during the interview process to be at your best, please let our recruiting team know.

UK applicants

We are proud of our commitment to diversity and equality (pursuant to the Equality Act 2010). We do not discriminate based upon race, religion or belief, colour, nationality, ethnic or national origin, gender, pregnancy or maternity, marital or civil partner status, sexual orientation, gender reassignment, age or disability.

US applicants

Compass Pathways is proud to be an equal opportunity employer. All employment decisions are based on business needs, job requirements, and individual qualifications, without regard to race, religion, color, national origin, sex (including pregnancy, childbirth, and related medical conditions), ethnicity, age, disability, sexual orientation, gender identity, gender expression, military service, genetic information, familial or marital status, or any other status, category, or characteristic protected by applicable law.

Sponsorship :

Unfortunately, we cannot sponsor employment visas and can only accept applications if you have employment rights in the country to which you are applying.

Data Privacy:

All data is confidential and protected by all legal and data privacy requirements, please see our recruitment Privacy Notice to learn more about how we process personal data.

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