Senior MS Scientist, ADC & Biologics Platform (Hybrid)

CytomX Therapeutics, Inc.; Emeryville (CA); Hybrid; USD 175,000 - 200,000; Full time

Job summary

CytomX Therapeutics, Inc. seeks a senior scientist to serve as the in-house mass spectrometry expert supporting Platform Biology, Bioanalysis, and ADC research programs.

You will design and execute studies that inform molecule characterization, metabolism, and mechanism of action, partnering across Research and Development to address analytical challenges. The role involves leading MS workflows, collaborating with cross-functional teams, mentoring scientists, and managing external CRO

Qualifications

• Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, Molecular Biology, or related discipline with 4–5+ years of industry experience.
• Experience with LC-MS/MS and mass spectrometry platforms (Orbitrap, triple quadrupole) in biotech/pharma/CRO environments.
• Expertise in MS-based characterization of proteins, mAbs, ADCs, or other complex biologics.

Responsibilities

• Serve as the subject matter expert for MS-based characterization of biologics, ADCs, linker payloads, and related biomolecules across discovery and development programs.
• Design, develop, and implement LC-MS/MS and high-resolution MS methods to support molecule characterization and related studies.
• Lead characterization of ADC attributes including DAR, conjugation heterogeneity, linker stability, payload-related species, and degradation products.

Skills

MS-based characterization

ADC analysis

Biologics analysis

Proteomics

Education

PhD in Analytical Chemistry or related field

Tools

Orbitrap

Triple quadrupole

Job description

CytomX Therapeutics, Inc. seeks a senior scientist to serve as the in-house mass spectrometry expert supporting Platform Biology, Bioanalysis, and ADC research programs.

You will design and execute studies that inform molecule characterization, metabolism, and mechanism of action, partnering across Research and Development to address analytical challenges. The role involves leading MS workflows, collaborating with cross-functional teams, mentoring scientists, and managing external CRO