Senior MS Scientist: Platform Biology & Bioanalysis (Hybrid)

CytomX Therapeutics; Emeryville (CA); Hybrid; USD 175,000 - 200,000; Full time

Job summary

CytomX Therapeutics is seeking an in-house mass spectrometry expert to support Platform Biology, Bioanalysis, and ADC research programs. You will design and execute MS studies informing molecule characterization, metabolism, catabolism, linker-payloads, biomarkers, and mechanism of action.

Your role partners across Research and Development to address analytical challenges, mentor scientists, and oversee external CROs while contributing to scientific leadership and publications.

Qualifications

• PhD with 4–5+ years in MS-based protein characterization.
• Hands-on expertise with LC-MS/MS using Orbitrap and QqQ.
• Experience characterizing biologics including ADCs is preferred.

Responsibilities

• Serve as the in-house MS expert supporting Platform Biology, Bioanalysis, and ADC programs.
• Design and execute MS studies to characterize molecules, metabolism, and mechanisms.
• Lead ADC DAR, conjugation heterogeneity, and payload-related analyses.
• Collaborate across R&D to translate MS data into decision making.
• Mentor scientists and oversee external CROs.
• Publish reports and present findings.
• Stay current with MS proteomics and analytical tech.
• Manage budget and resources for the team.

Skills

Mass spectrometry

LC-MS/MS

Proteomics

Biologics analysis

Education

PhD in Analytical Chemistry or related field

Tools

Orbitrap

Triple quadrupole

Mass spectrometry workflows

Job description

CytomX Therapeutics is seeking an in-house mass spectrometry expert to support Platform Biology, Bioanalysis, and ADC research programs. You will design and execute MS studies informing molecule characterization, metabolism, catabolism, linker-payloads, biomarkers, and mechanism of action.

Your role partners across Research and Development to address analytical challenges, mentor scientists, and oversee external CROs while contributing to scientific leadership and publications.