Senior LVV Downstream Process Engineer & Modeling Lead

BioSpace; New Jersey; On-site; USD 146,000 - 192,000; Full time

Benefits offered by this job

Performance-based bonus

Equity

Health insurance

401(k) with company match

Paid parental leave

Job summary

Legend Biotech, a leading biotechnology company, seeks a Principal Engineer for Lentivirus Downstream Process Development to lead process design, optimization, and scale-up in Somerset, NJ. The role focuses on developing robust LVV purification strategies, combined with modeling and analytics to support GMP manufacturing.

The candidate will guide a team of scientists, implement APC strategies, and ensure seamless technology transfer for clinical programs, while maintaining strict regulatory

Qualifications

• Advanced degree in Chemical Engineering, Biomedical Engineering, or related field.
• 8+ years (PhD) or 10+ years (MS) in process development or manufacturing within biotech/pharma.
• Experience with bioprocessing modeling, simulation, and interaction of biomolecules and machinery.
• Experience with Python and MATLAB.
• Deep experience in purification, chromatography, and TFF.
• Strong GMP and CMC knowledge for clinical programs.
• Knowledge of lentiviral vector technologies.
• Excellent leadership and communication skills; able to lead teams.

Responsibilities

• Design, optimize, and scale LVV downstream purification processes.
• Develop mechanistic and hybrid models to guide downstream development.
• Apply data analytics and ML to derive process insights.
• Oversee transfer to GMP manufacturing and tech transfer between sites.
• Lead cross-functional teams and communicate progress and risks.

Skills

Leadership

Communication skills

Problem solving

Creative thinking

Education

PhD in Chemical Engineering

MS in Bioprocessing or related field

Tools

Python

MATLAB

Job description

Legend Biotech, a leading biotechnology company, seeks a Principal Engineer for Lentivirus Downstream Process Development to lead process design, optimization, and scale-up in Somerset, NJ. The role focuses on developing robust LVV purification strategies, combined with modeling and analytics to support GMP manufacturing.

The candidate will guide a team of scientists, implement APC strategies, and ensure seamless technology transfer for clinical programs, while maintaining strict regulatory