Senior Lentivirus Upstream Process Lead

Legend Biotech US; New Jersey; On-site; USD 127,313 - 167,099; Full time

Benefits offered by this job

Medical, dental, vision insurance

401(k) employer match

Paid parental leave (8 weeks)

Job summary

Legend Biotech US in Somerset, NJ seeks a Senior Scientist for Lentivirus Upstream Processing. You will design and optimize upstream production, including seed train expansion, HEK293/HEK293T culture, and bioreactor scale-up to deliver high-titer, GMP-ready vectors for clinical programs.

Requirements include an advanced degree (PhD preferred) and 5–8 years (PhD) or 8+ years (MS) in biotech; GMP experience; strong cross-functional collaboration and documentation skills to support tech transfer

Qualifications

• Advanced degree required in a related field (PhD preferred).
• Experience in process development or manufacturing within biotech/pharma.
• Hands-on mammalian cell culture with HEK293/HEK293T for viral vectors.

Responsibilities

• Design and execute upstream strategies for lentiviral vector production.
• Optimize seed train expansion and transient transfection to improve titer.
• Support scale-up/scale-down models and tech transfer to GMP manufacture.
• Collaborate with CMC, Analytical Development, and Downstream teams to ensure alignment.
• Document protocols, QC/assay parameters, and regulatory sections as needed.

Skills

Mammalian cell culture

Seed train expansion

Transient transfection

Bioreactor scale-up

GMP/CMC knowledge

Process development

Data analysis

Cross-functional collaboration

Education

PhD in Chemical Engineering/Bioengineering

Job description

Legend Biotech US in Somerset, NJ seeks a Senior Scientist for Lentivirus Upstream Processing. You will design and optimize upstream production, including seed train expansion, HEK293/HEK293T culture, and bioreactor scale-up to deliver high-titer, GMP-ready vectors for clinical programs.

Requirements include an advanced degree (PhD preferred) and 5–8 years (PhD) or 8+ years (MS) in biotech; GMP experience; strong cross-functional collaboration and documentation skills to support tech transfer