Senior Lentiviral Upstream Process Scientist

Legend Biotech EU; Maine; On-site; USD 127,000 - 167,000; Full time

Benefits offered by this job

Medical insurance

Dental and vision

401(k) with match

Parental leave

Paid time off

Well-being programs

Job summary

Legend Biotech is seeking a Sr. Scientist, Lentiviral Upstream Processing to join the Technical Development team in Somerset, NJ.

The role focuses on designing and optimizing upstream production for lentiviral vectors, with emphasis on seed train, mammalian culture, transfection, and scale-up to support GMP manufacturing. The candidate will collaborate with CMC Project Management and other leads, ensuring robust processes, phase-appropriate scaling, and effective tech transfer while maintaining

Qualifications

• PhD preferred or MS with strong experience in biotech upstream processing.
• 5–8 years (PhD) or 8+ years (MS) in process development or manufacturing.
• Experience with HEK293/HEK293T and viral vector production.
• GMP manufacturing and early-phase CMC exposure.
• Strong problem-solving and collaboration skills.

Responsibilities

• Design and execute experimental strategies for lentiviral vector upstream production.
• Develop and optimize upstream processes including seed train expansion and large-scale transfection.
• Support bioreactor scale-up/scale-down models for GMP manufacturing.
• Assist in technology transfer and troubleshooting during clinical production runs.
• Document study parameters, feeding strategies, and performance limits.

Skills

Lentiviral upstream

Mammalian cell culture

Bioreactor scale-up

GMP/CMC knowledge

Analytical thinking

Regulatory documentation

Cross-functional collaboration

Troubleshooting

Tech transfer support

Education

PhD or MS in relevant field

Job description

Legend Biotech is seeking a Sr. Scientist, Lentiviral Upstream Processing to join the Technical Development team in Somerset, NJ.

The role focuses on designing and optimizing upstream production for lentiviral vectors, with emphasis on seed train, mammalian culture, transfection, and scale-up to support GMP manufacturing. The candidate will collaborate with CMC Project Management and other leads, ensuring robust processes, phase-appropriate scaling, and effective tech transfer while maintaining