Senior LNP Formulation & Analytics Scientist

Vertex Pharmaceuticals LLC; Boston (MA); On-site; USD 88,000 - 132,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Paid time off

Job summary

Vertex Pharmaceuticals is seeking an experienced Principal Research Associate to join the LNP Discovery team in a fast-paced environment. You will formulate, purify, and analyze LNPs from small to large scale, drive method optimization, and partner with colleagues across disciplines to improve yield, scalability, and product quality.

Key duties include performing LNP analytics, following SOPs with ELN records, and supporting DoE-driven method development.

Qualifications

• 5+ years industry experience in LNP formulation and analytics.
• Experience with DoE-driven method development.
• Strong collaboration and scientific rigor.

Responsibilities

• Formulate, purify, and analyze LNPs at small- and large-scale.
• Run LNP analytics: size, encapsulation, pKa, osmolality, endotoxin.
• Follow SOPs and maintain ELN records.
• Troubleshoot and optimize formulations and processes.
• Present experimental designs and data in team meetings.

Skills

LNP formulation

Purification techniques

LNP analytics

DoE-driven development

LNP manufacturing support

Education

Master's degree in Chemistry or related

Bachelor's degree in Chemistry or related

Tools

LNP mixing devices

TFF systems

LC-MS / assay development

Job description

Vertex Pharmaceuticals is seeking an experienced Principal Research Associate to join the LNP Discovery team in a fast-paced environment. You will formulate, purify, and analyze LNPs from small to large scale, drive method optimization, and partner with colleagues across disciplines to improve yield, scalability, and product quality.

Key duties include performing LNP analytics, following SOPs with ELN records, and supporting DoE-driven method development.