Principal Research Associate, LNP Formulation & Analytics

Vertex Pharmaceuticals; Center (TX); On-site; USD 88,000 - 132,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Commuting subsidy

Education assistance

Paid time off including company shut

Job summary

Vertex Pharmaceuticals is seeking an experienced Principal Research Associate to join the LNP Discovery team in a fast-paced, collaborative setting. You will formulate, purify, and analyze LNPs from small to large scale, driving DoE-driven method development and process optimization to improve yield and product quality.

You will work with colleagues across disciplines, troubleshoot protocols, maintain ELN records, and present data clearly in meetings.

Qualifications

• Master’s or Bachelor’s degree with significant industry experience in LNP formulation or related fields.
• Experience in planning and executing DoE-driven method development.
• Proficiency with LNP analytics and purification methods.
• Ability to work in a collaborative, fast-paced drug development environment.
• Strong communication and record-keeping in ELN systems.

Responsibilities

• Formulate, purify, and analyze LNPs at small- and large-scale per SOPs.
• Run routine LNP analytics including size, encapsulation, pKa, osmolality, and endotoxin.
• Troubleshoot protocol issues and identify improvement opportunities.
• Support formulation and process development to improve yield and scalability.
• Meet deadlines and adapt to strategic changes in a dynamic environment.
• Present experimental designs and data in team and cross-functional meetings.

Skills

LNP formation

Microfluidic mixing

Impingement Jet Mixing

TFF purification

DoE experiments

LNP analytics

pKa measurement

Endotoxin testing

LC-MS

Data presentation

Education

Master’s degree in Chemistry/Pharmaceutical Science/Chemical Engineering/Biochemistry, or related with 5+ years industry experience

Bachelor’s degree in Chemistry/Pharmaceutical Science/Chemical Engineering/Biochemistry, or related with 7+ years industry experience

Tools

TFF systems

Mixer systems

LC-MS instruments

DoE software

Job description

Vertex Pharmaceuticals is seeking an experienced Principal Research Associate to join the LNP Discovery team in a fast-paced, collaborative setting. You will formulate, purify, and analyze LNPs from small to large scale, driving DoE-driven method development and process optimization to improve yield and product quality.

You will work with colleagues across disciplines, troubleshoot protocols, maintain ELN records, and present data clearly in meetings.