Senior Lentivirus Upstream Process Scientist (Scale-Up)

BioSpace; New Jersey; On-site; USD 127,000 - 167,000; Full time

Benefits offered by this job

Medical, dental, vision

401(k) match

Parental leave

Job summary

Legend Biotech is seeking a Senior Scientist, Lentivirus Upstream Processing in Somerset, NJ, to design and optimize upstream production of LVV. You will develop seed trains, mammalian culture, and transfection strategies to deliver high-titer vectors for clinical programs.

The role requires hands-on process development, scale-up expertise, and collaboration with GMP teams to ensure robust, scalable manufacturing and timely tech transfers.

Qualifications

• Advanced degree in Chemical Engineering, Bioengineering, or related field.
• 5–8 years (PhD) or 8+ years (MS) in biotech process development/manufacturing.
• Experience with mammalian cell culture and viral vector technologies.
• GMP manufacturing experience for early-phase clinical trials.

Responsibilities

• Design/execute upstream strategies for lentiviral vector production.
• Develop/optimize seed train, feeding strategy, and transfection processes.
• Scale-up/scale-down bioreactor models; ensure process comparability.
• Support tech transfer to GMP manufacturing and CDMOs.
• Document studies and contribute to regulatory submissions (IND).
• Collaborate with CMC PM and other leads to meet timelines.

Skills

HEK293/HEK293T culture

Lentiviral vectors

Seed train expansion

Transient transfection

Bioreactor scale-up

GMP/CMC knowledge

Process development

Education

PhD preferred

MS in related field

Tools

Bioreactors

Job description

Legend Biotech is seeking a Senior Scientist, Lentivirus Upstream Processing in Somerset, NJ, to design and optimize upstream production of LVV. You will develop seed trains, mammalian culture, and transfection strategies to deliver high-titer vectors for clinical programs.

The role requires hands-on process development, scale-up expertise, and collaboration with GMP teams to ensure robust, scalable manufacturing and timely tech transfers.