Senior Vector Downstream Engineer – LVV, GMP & Modeling

BioNJ Inc.; New Jersey; On-site; USD 140,000 - 200,000; Full time

Job summary

Legend Biotech in Somerset, NJ seeks a Senior Engineer / Principal Engineer for Vector Downstream to design, optimize, and scale purification processes for LVV in a GMP setting. You will build mechanistic and AI-enabled models, apply mass transfer and chromatography expertise, and drive tech transfer from bench to manufacturing while collaborating with cross-functional teams.

Requires 6+ years (PhD) or 8+ years (MS) in bioprocess development or manufacturing, with strong leadership and

Qualifications

• Advanced degree (PhD preferred, or MS) in a related field.
• 6+ years (PhD) or 8+ years (MS) of experience in bioprocess development or manufacturing.
• Strong knowledge of bioprocess modeling and downstream processing.

Responsibilities

• Design, optimize, and scale LVV downstream purification processes.
• Develop mechanistic and AI-enabled models for process understanding.
• Lead or support tech transfer from bench to GMP manufacturing.
• Apply mass transfer, fluid dynamics, and thermodynamics to models.
• Collaborate with upstream/analytical teams and cross-functional partners.

Skills

Bioprocess modeling

AI-enabled development

Data analytics

Team leadership

Education

PhD in Chemical/Biomedical/Bioprocess Engineering

MS in Chemical/Biomedical/Bioprocess Engineering

Tools

Python

MATLAB

GMP/CMC familiarity

Job description

Legend Biotech in Somerset, NJ seeks a Senior Engineer / Principal Engineer for Vector Downstream to design, optimize, and scale purification processes for LVV in a GMP setting. You will build mechanistic and AI-enabled models, apply mass transfer and chromatography expertise, and drive tech transfer from bench to manufacturing while collaborating with cross-functional teams.

Requires 6+ years (PhD) or 8+ years (MS) in bioprocess development or manufacturing, with strong leadership and